<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2025 Workiva-->
<!--r:16cb8d7f-75d4-4717-888e-de892581faf7,g:82634e3d-1612-4d82-a960-ea91edfe7341-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://cumberlandpharma.com/role/DocumentandEntityInformationDocument" xlink:type="simple" xlink:href="cpix-20250219.xsd#DocumentandEntityInformationDocument"/>
  <link:presentationLink xlink:role="http://cumberlandpharma.com/role/DocumentandEntityInformationDocument" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_4f2a09d1-ae9d-44e5-b3b5-ac5696ac3a7b" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_aa55ce8a-829b-4a9c-803c-78882a76d09d" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4f2a09d1-ae9d-44e5-b3b5-ac5696ac3a7b" xlink:to="loc_dei_DocumentType_aa55ce8a-829b-4a9c-803c-78882a76d09d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_03dd77e5-ffb5-4d52-ae54-5a4305f25fd3" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4f2a09d1-ae9d-44e5-b3b5-ac5696ac3a7b" xlink:to="loc_dei_DocumentPeriodEndDate_03dd77e5-ffb5-4d52-ae54-5a4305f25fd3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_a0f64d94-4c0f-4d27-97ef-8f33f85b296f" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4f2a09d1-ae9d-44e5-b3b5-ac5696ac3a7b" xlink:to="loc_dei_EntityRegistrantName_a0f64d94-4c0f-4d27-97ef-8f33f85b296f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_ce36938a-0bc3-41c3-b1fa-21b399b5332b" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4f2a09d1-ae9d-44e5-b3b5-ac5696ac3a7b" xlink:to="loc_dei_EntityCentralIndexKey_ce36938a-0bc3-41c3-b1fa-21b399b5332b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_8c816ec6-8660-4830-8220-0ec155ff6896" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4f2a09d1-ae9d-44e5-b3b5-ac5696ac3a7b" xlink:to="loc_dei_AmendmentFlag_8c816ec6-8660-4830-8220-0ec155ff6896" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_a15d0d86-95eb-4c76-83cd-f7eea7336200" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4f2a09d1-ae9d-44e5-b3b5-ac5696ac3a7b" xlink:to="loc_dei_EntityIncorporationStateCountryCode_a15d0d86-95eb-4c76-83cd-f7eea7336200" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_3aee6bdb-89d4-4a75-b9e6-2dadb16cf16a" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4f2a09d1-ae9d-44e5-b3b5-ac5696ac3a7b" xlink:to="loc_dei_EntityFileNumber_3aee6bdb-89d4-4a75-b9e6-2dadb16cf16a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_f1685d9e-adb0-42b6-8395-7b5c6df0598e" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4f2a09d1-ae9d-44e5-b3b5-ac5696ac3a7b" xlink:to="loc_dei_EntityTaxIdentificationNumber_f1685d9e-adb0-42b6-8395-7b5c6df0598e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_fdc75359-5a12-4f6b-ad6e-359793872682" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4f2a09d1-ae9d-44e5-b3b5-ac5696ac3a7b" xlink:to="loc_dei_CityAreaCode_fdc75359-5a12-4f6b-ad6e-359793872682" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_240b0090-babe-409a-9cce-c0d0c32182a0" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4f2a09d1-ae9d-44e5-b3b5-ac5696ac3a7b" xlink:to="loc_dei_LocalPhoneNumber_240b0090-babe-409a-9cce-c0d0c32182a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_fa08f16f-bd53-400e-ab79-c5f239cdbb10" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4f2a09d1-ae9d-44e5-b3b5-ac5696ac3a7b" xlink:to="loc_dei_WrittenCommunications_fa08f16f-bd53-400e-ab79-c5f239cdbb10" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_b43a254c-69d7-4ae6-b7b0-c03199974068" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4f2a09d1-ae9d-44e5-b3b5-ac5696ac3a7b" xlink:to="loc_dei_SolicitingMaterial_b43a254c-69d7-4ae6-b7b0-c03199974068" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_ede7ffb6-a300-429e-a64a-cf3b3d1dc9be" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4f2a09d1-ae9d-44e5-b3b5-ac5696ac3a7b" xlink:to="loc_dei_PreCommencementTenderOffer_ede7ffb6-a300-429e-a64a-cf3b3d1dc9be" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_de3da0fb-ebce-4dac-a2d0-891e72911add" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4f2a09d1-ae9d-44e5-b3b5-ac5696ac3a7b" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_de3da0fb-ebce-4dac-a2d0-891e72911add" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_fbf84f26-0f0b-4c26-bd42-46415271be21" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4f2a09d1-ae9d-44e5-b3b5-ac5696ac3a7b" xlink:to="loc_dei_Security12bTitle_fbf84f26-0f0b-4c26-bd42-46415271be21" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_808f853a-f399-4f3e-b354-e4de12f7a90e" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4f2a09d1-ae9d-44e5-b3b5-ac5696ac3a7b" xlink:to="loc_dei_TradingSymbol_808f853a-f399-4f3e-b354-e4de12f7a90e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_8e81525f-19e5-4f96-80a9-97a91220d38e" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4f2a09d1-ae9d-44e5-b3b5-ac5696ac3a7b" xlink:to="loc_dei_SecurityExchangeName_8e81525f-19e5-4f96-80a9-97a91220d38e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_db399c37-386c-47fc-8d3a-c5d5999227af" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4f2a09d1-ae9d-44e5-b3b5-ac5696ac3a7b" xlink:to="loc_dei_EntityEmergingGrowthCompany_db399c37-386c-47fc-8d3a-c5d5999227af" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_08d0f836-c8d8-4d00-b245-26e9f5ec1533" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4f2a09d1-ae9d-44e5-b3b5-ac5696ac3a7b" xlink:to="loc_dei_EntityAddressAddressLine1_08d0f836-c8d8-4d00-b245-26e9f5ec1533" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_8acf7240-f836-4b99-a490-5792c0d46f23" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4f2a09d1-ae9d-44e5-b3b5-ac5696ac3a7b" xlink:to="loc_dei_EntityAddressCityOrTown_8acf7240-f836-4b99-a490-5792c0d46f23" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_e04e59ef-6153-4f8f-957e-d7e0f62d3867" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4f2a09d1-ae9d-44e5-b3b5-ac5696ac3a7b" xlink:to="loc_dei_EntityAddressStateOrProvince_e04e59ef-6153-4f8f-957e-d7e0f62d3867" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_944fe5ea-d274-47e3-b1f0-1972f4f17f22" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4f2a09d1-ae9d-44e5-b3b5-ac5696ac3a7b" xlink:to="loc_dei_EntityAddressPostalZipCode_944fe5ea-d274-47e3-b1f0-1972f4f17f22" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
