<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2023 Workiva-->
<!--r:f3294900-4a6d-4934-9914-8de8a2261475,g:98ef8ed7-f771-4377-a070-411ae3070b66-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.cumberlandpharma.com/role/ConsolidatedStatementsofOperations" xlink:type="simple" xlink:href="cpix-20221231.xsd#ConsolidatedStatementsofOperations"/>
  <link:definitionLink xlink:role="http://www.cumberlandpharma.com/role/ConsolidatedStatementsofOperations" xlink:type="extended" id="ia9e99b0e827b4899bf89e3597c32b91d_ConsolidatedStatementsofOperations">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_b913405e-6702-4d4e-9354-a6597af75bf8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesAbstract_a560a093-25be-4638-8d0b-e26a1db91f2e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenuesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b913405e-6702-4d4e-9354-a6597af75bf8" xlink:to="loc_us-gaap_RevenuesAbstract_a560a093-25be-4638-8d0b-e26a1db91f2e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_9151ee6b-0d75-4b54-90b4-13449e158f70" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Revenues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_a560a093-25be-4638-8d0b-e26a1db91f2e" xlink:to="loc_us-gaap_Revenues_9151ee6b-0d75-4b54-90b4-13449e158f70" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpensesAbstract_84123000-1ba8-4498-8c69-d96f64aeca8a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostsAndExpensesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b913405e-6702-4d4e-9354-a6597af75bf8" xlink:to="loc_us-gaap_CostsAndExpensesAbstract_84123000-1ba8-4498-8c69-d96f64aeca8a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_356d4bf9-a10e-40f9-a585-159147cfff18" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_84123000-1ba8-4498-8c69-d96f64aeca8a" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_356d4bf9-a10e-40f9-a585-159147cfff18" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingAndMarketingExpense_d611f36c-a654-41e7-a71e-40d9d973e3b6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SellingAndMarketingExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_84123000-1ba8-4498-8c69-d96f64aeca8a" xlink:to="loc_us-gaap_SellingAndMarketingExpense_d611f36c-a654-41e7-a71e-40d9d973e3b6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_f2e35393-e0e5-450b-89ea-326b972f3b34" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_84123000-1ba8-4498-8c69-d96f64aeca8a" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_f2e35393-e0e5-450b-89ea-326b972f3b34" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_08430f5a-5543-4e34-8575-0279b433b7ef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_84123000-1ba8-4498-8c69-d96f64aeca8a" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_08430f5a-5543-4e34-8575-0279b433b7ef" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_ad03585c-0138-408a-95ec-0e8bd0857acc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_84123000-1ba8-4498-8c69-d96f64aeca8a" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_ad03585c-0138-408a-95ec-0e8bd0857acc" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_fce0f67c-bf01-4e81-be91-76fc9fb3035e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostsAndExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_84123000-1ba8-4498-8c69-d96f64aeca8a" xlink:to="loc_us-gaap_CostsAndExpenses_fce0f67c-bf01-4e81-be91-76fc9fb3035e" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_ea328df7-8a4f-45dc-98d5-8fb8b37e1fca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b913405e-6702-4d4e-9354-a6597af75bf8" xlink:to="loc_us-gaap_OperatingIncomeLoss_ea328df7-8a4f-45dc-98d5-8fb8b37e1fca" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_e7932b01-f1eb-43c3-be21-aefb4c20c41a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b913405e-6702-4d4e-9354-a6597af75bf8" xlink:to="loc_us-gaap_InvestmentIncomeInterest_e7932b01-f1eb-43c3-be21-aefb4c20c41a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherIncome_a9a11545-5602-48af-8b5a-ba2458cd331f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherIncome"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b913405e-6702-4d4e-9354-a6597af75bf8" xlink:to="loc_us-gaap_OtherIncome_a9a11545-5602-48af-8b5a-ba2458cd331f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InsuredEventGainLoss_bb1214c3-57cf-44a5-8710-08eef18a2155" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InsuredEventGainLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b913405e-6702-4d4e-9354-a6597af75bf8" xlink:to="loc_us-gaap_InsuredEventGainLoss_bb1214c3-57cf-44a5-8710-08eef18a2155" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_bbe51062-8cda-41cf-a433-f201aa64ac7e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b913405e-6702-4d4e-9354-a6597af75bf8" xlink:to="loc_us-gaap_InterestExpense_bbe51062-8cda-41cf-a433-f201aa64ac7e" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_d046fb62-732e-4ef7-aa43-78e61eb1e361" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b913405e-6702-4d4e-9354-a6597af75bf8" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_d046fb62-732e-4ef7-aa43-78e61eb1e361" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_ccdc04ce-8ae1-49aa-9b98-d13a0a614f0e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b913405e-6702-4d4e-9354-a6597af75bf8" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_ccdc04ce-8ae1-49aa-9b98-d13a0a614f0e" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_f721959a-98bc-45f4-a40a-5812070ee31b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b913405e-6702-4d4e-9354-a6597af75bf8" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_f721959a-98bc-45f4-a40a-5812070ee31b" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_9280d99d-8daa-4cb8-ae81-6b32771cc2ef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b913405e-6702-4d4e-9354-a6597af75bf8" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_9280d99d-8daa-4cb8-ae81-6b32771cc2ef" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_356aad5f-5112-473b-b704-f1f7d8d73ad0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b913405e-6702-4d4e-9354-a6597af75bf8" xlink:to="loc_us-gaap_ProfitLoss_356aad5f-5112-473b-b704-f1f7d8d73ad0" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_6bae5eaf-133c-4008-a80b-f271c9247bd4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b913405e-6702-4d4e-9354-a6597af75bf8" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_6bae5eaf-133c-4008-a80b-f271c9247bd4" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_725d4db8-0ee8-4a83-8573-0ebd691b4ee8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b913405e-6702-4d4e-9354-a6597af75bf8" xlink:to="loc_us-gaap_NetIncomeLoss_725d4db8-0ee8-4a83-8573-0ebd691b4ee8" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_fc15eb6e-5426-45db-8e72-498e49e161bb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b913405e-6702-4d4e-9354-a6597af75bf8" xlink:to="loc_us-gaap_EarningsPerShareAbstract_fc15eb6e-5426-45db-8e72-498e49e161bb" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_e12f7eba-9927-4b5e-a1c4-790fd6df7001" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperationsPerBasicShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_fc15eb6e-5426-45db-8e72-498e49e161bb" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_e12f7eba-9927-4b5e-a1c4-790fd6df7001" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare_a89fc7c8-7c3c-43a3-8f90-ecb023d39634" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_fc15eb6e-5426-45db-8e72-498e49e161bb" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare_a89fc7c8-7c3c-43a3-8f90-ecb023d39634" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_3b9dd7e5-928b-4887-8f50-27c52d3a6917" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_fc15eb6e-5426-45db-8e72-498e49e161bb" xlink:to="loc_us-gaap_EarningsPerShareBasic_3b9dd7e5-928b-4887-8f50-27c52d3a6917" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_64673057-acc2-4fec-9ca9-fb89733bb8e2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_fc15eb6e-5426-45db-8e72-498e49e161bb" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_64673057-acc2-4fec-9ca9-fb89733bb8e2" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare_024fc8cb-7bd8-4644-894f-34d38d7edcc4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_fc15eb6e-5426-45db-8e72-498e49e161bb" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare_024fc8cb-7bd8-4644-894f-34d38d7edcc4" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_1b00fbac-4333-4105-b20c-fd2cf28464ff" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_fc15eb6e-5426-45db-8e72-498e49e161bb" xlink:to="loc_us-gaap_EarningsPerShareDiluted_1b00fbac-4333-4105-b20c-fd2cf28464ff" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_655eb915-1dd5-4155-926b-9f840df65713" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_b913405e-6702-4d4e-9354-a6597af75bf8" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_655eb915-1dd5-4155-926b-9f840df65713" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_fd4b2f9f-312a-4bef-9ffb-e12af42c8fde" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_655eb915-1dd5-4155-926b-9f840df65713" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_fd4b2f9f-312a-4bef-9ffb-e12af42c8fde" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_5493f149-727a-415c-a52d-fc230a7bae9c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_655eb915-1dd5-4155-926b-9f840df65713" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_5493f149-727a-415c-a52d-fc230a7bae9c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_9304a0e2-a0c2-4977-b784-1e6ffa05caba" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_b913405e-6702-4d4e-9354-a6597af75bf8" xlink:to="loc_us-gaap_StatementTable_9304a0e2-a0c2-4977-b784-1e6ffa05caba" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_24c982f4-ee9a-4011-baca-308c6a3a217f" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_9304a0e2-a0c2-4977-b784-1e6ffa05caba" xlink:to="loc_srt_ProductOrServiceAxis_24c982f4-ee9a-4011-baca-308c6a3a217f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_24c982f4-ee9a-4011-baca-308c6a3a217f_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_24c982f4-ee9a-4011-baca-308c6a3a217f" xlink:to="loc_srt_ProductsAndServicesDomain_24c982f4-ee9a-4011-baca-308c6a3a217f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_5099d65c-7543-40c7-96e4-bf3faf8572a2" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_24c982f4-ee9a-4011-baca-308c6a3a217f" xlink:to="loc_srt_ProductsAndServicesDomain_5099d65c-7543-40c7-96e4-bf3faf8572a2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductMember_75bbebba-1dab-48b9-8de1-2a76478c22df" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProductMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_5099d65c-7543-40c7-96e4-bf3faf8572a2" xlink:to="loc_us-gaap_ProductMember_75bbebba-1dab-48b9-8de1-2a76478c22df" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ManufacturedProductOtherMember_60115f0b-993d-4a2a-ba31-43f0fc07a68c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ManufacturedProductOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_5099d65c-7543-40c7-96e4-bf3faf8572a2" xlink:to="loc_us-gaap_ManufacturedProductOtherMember_60115f0b-993d-4a2a-ba31-43f0fc07a68c" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cumberlandpharma.com/role/ConsolidatedStatementsofEquity" xlink:type="simple" xlink:href="cpix-20221231.xsd#ConsolidatedStatementsofEquity"/>
  <link:definitionLink xlink:role="http://www.cumberlandpharma.com/role/ConsolidatedStatementsofEquity" xlink:type="extended" id="id939a19f35ee4430bdb2c9913a7bd70e_ConsolidatedStatementsofEquity">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_55fed691-fa85-4d7a-8243-3592475270a1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_88046fb2-3431-468b-9ebb-02b11b401a58" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_55fed691-fa85-4d7a-8243-3592475270a1" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_88046fb2-3431-468b-9ebb-02b11b401a58" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_29a950f4-ecf6-4f58-9f2e-5160fd7e5d24" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_88046fb2-3431-468b-9ebb-02b11b401a58" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_29a950f4-ecf6-4f58-9f2e-5160fd7e5d24" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_d7cb3bc0-18e0-4513-94f2-02f0758198e4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_88046fb2-3431-468b-9ebb-02b11b401a58" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_d7cb3bc0-18e0-4513-94f2-02f0758198e4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_3f7a243f-cb40-4f68-87ae-8921cf2a97da" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_88046fb2-3431-468b-9ebb-02b11b401a58" xlink:to="loc_us-gaap_NetIncomeLoss_3f7a243f-cb40-4f68-87ae-8921cf2a97da" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_15b00173-d7af-4e84-86ee-9a06009c5dcd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_88046fb2-3431-468b-9ebb-02b11b401a58" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_15b00173-d7af-4e84-86ee-9a06009c5dcd" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_52246a98-41c9-4ea4-8be8-f0531be476d4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_88046fb2-3431-468b-9ebb-02b11b401a58" xlink:to="loc_us-gaap_ProfitLoss_52246a98-41c9-4ea4-8be8-f0531be476d4" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRedeemedOrCalledDuringPeriodShares_cbab720b-b704-4c40-94d4-68f69f979b18" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRedeemedOrCalledDuringPeriodShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_88046fb2-3431-468b-9ebb-02b11b401a58" xlink:to="loc_us-gaap_StockRedeemedOrCalledDuringPeriodShares_cbab720b-b704-4c40-94d4-68f69f979b18" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRedeemedOrCalledDuringPeriodValue_38428cf0-70d5-4792-994d-092a787bc456" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRedeemedOrCalledDuringPeriodValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_88046fb2-3431-468b-9ebb-02b11b401a58" xlink:to="loc_us-gaap_StockRedeemedOrCalledDuringPeriodValue_38428cf0-70d5-4792-994d-092a787bc456" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_71ad5ba4-7225-4288-b800-15f451f33409" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_88046fb2-3431-468b-9ebb-02b11b401a58" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_71ad5ba4-7225-4288-b800-15f451f33409" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_919348d2-3247-4c2e-b289-b76a7f504a26" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_88046fb2-3431-468b-9ebb-02b11b401a58" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_919348d2-3247-4c2e-b289-b76a7f504a26" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodShares_d8404652-eb7f-4d6a-b7e5-45adb4e1f18a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRepurchasedDuringPeriodShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_88046fb2-3431-468b-9ebb-02b11b401a58" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodShares_d8404652-eb7f-4d6a-b7e5-45adb4e1f18a" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodValue_b05f5a73-6937-4943-b63b-d26b4fbbf7cb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRepurchasedDuringPeriodValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_88046fb2-3431-468b-9ebb-02b11b401a58" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodValue_b05f5a73-6937-4943-b63b-d26b4fbbf7cb" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_0c7c41bb-6ff9-44c5-92fb-c6c388b28870" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_210bb1f5-ca2a-44e5-9f46-7ece3a6d24c0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_2ee2a8d2-e3c7-4925-a6e8-9fc6735beb4c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_55fed691-fa85-4d7a-8243-3592475270a1" xlink:to="loc_us-gaap_StatementTable_2ee2a8d2-e3c7-4925-a6e8-9fc6735beb4c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_fde97187-8844-4077-8a47-f0d18f7bb54f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_2ee2a8d2-e3c7-4925-a6e8-9fc6735beb4c" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_fde97187-8844-4077-8a47-f0d18f7bb54f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_fde97187-8844-4077-8a47-f0d18f7bb54f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_fde97187-8844-4077-8a47-f0d18f7bb54f" xlink:to="loc_us-gaap_EquityComponentDomain_fde97187-8844-4077-8a47-f0d18f7bb54f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_c19329a0-4cfb-4d19-817c-304bb598a84a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_fde97187-8844-4077-8a47-f0d18f7bb54f" xlink:to="loc_us-gaap_EquityComponentDomain_c19329a0-4cfb-4d19-817c-304bb598a84a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_e4fe6a16-abed-486c-bb3c-b1aceba101a5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_c19329a0-4cfb-4d19-817c-304bb598a84a" xlink:to="loc_us-gaap_CommonStockMember_e4fe6a16-abed-486c-bb3c-b1aceba101a5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_45a168d8-7291-43ca-bf42-da0baedce858" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_c19329a0-4cfb-4d19-817c-304bb598a84a" xlink:to="loc_us-gaap_RetainedEarningsMember_45a168d8-7291-43ca-bf42-da0baedce858" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncontrollingInterestMember_2eb9de6e-5cba-487d-87cb-253c093955ab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_c19329a0-4cfb-4d19-817c-304bb598a84a" xlink:to="loc_us-gaap_NoncontrollingInterestMember_2eb9de6e-5cba-487d-87cb-253c093955ab" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cumberlandpharma.com/role/OrganizationNarrativeDetails" xlink:type="simple" xlink:href="cpix-20221231.xsd#OrganizationNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.cumberlandpharma.com/role/OrganizationNarrativeDetails" xlink:type="extended" id="i7f33d63e4a8844a8a11622d0f5c4e4c2_OrganizationNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInformationLineItems_285ffdd9-f89b-4eac-b348-2101ec07dd44" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncontrollingInterestAbstract_5e771935-dac9-4fdc-8eaf-1cd33f0eccd3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NoncontrollingInterestAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_285ffdd9-f89b-4eac-b348-2101ec07dd44" xlink:to="loc_us-gaap_NoncontrollingInterestAbstract_5e771935-dac9-4fdc-8eaf-1cd33f0eccd3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncontrollingInterestIncreaseFromSaleOfParentEquityInterest_2ac2b9bf-07b9-4831-829f-43e26ad508e0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NoncontrollingInterestIncreaseFromSaleOfParentEquityInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NoncontrollingInterestAbstract_5e771935-dac9-4fdc-8eaf-1cd33f0eccd3" xlink:to="loc_us-gaap_NoncontrollingInterestIncreaseFromSaleOfParentEquityInterest_2ac2b9bf-07b9-4831-829f-43e26ad508e0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_SubsidiaryInvestmentPurchaseOfShares_d6253f9f-2c13-4751-9370-e93267edb112" xlink:href="cpix-20221231.xsd#cpix_SubsidiaryInvestmentPurchaseOfShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NoncontrollingInterestAbstract_5e771935-dac9-4fdc-8eaf-1cd33f0eccd3" xlink:to="loc_cpix_SubsidiaryInvestmentPurchaseOfShares_d6253f9f-2c13-4751-9370-e93267edb112" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_ContributionOfCashAdditionalSharesPurchased_5c1ba1d3-38b0-4477-a493-4876e8de44e8" xlink:href="cpix-20221231.xsd#cpix_ContributionOfCashAdditionalSharesPurchased"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NoncontrollingInterestAbstract_5e771935-dac9-4fdc-8eaf-1cd33f0eccd3" xlink:to="loc_cpix_ContributionOfCashAdditionalSharesPurchased_5c1ba1d3-38b0-4477-a493-4876e8de44e8" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_IntercompanyLoansPayableConvertedAmount_92cf3db8-a9f5-4925-a623-1a670f0a6868" xlink:href="cpix-20221231.xsd#cpix_IntercompanyLoansPayableConvertedAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NoncontrollingInterestAbstract_5e771935-dac9-4fdc-8eaf-1cd33f0eccd3" xlink:to="loc_cpix_IntercompanyLoansPayableConvertedAmount_92cf3db8-a9f5-4925-a623-1a670f0a6868" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_SubsidiaryInvestmentPaymentsForReturnOfCapital_48e52e1b-93ae-48d9-981b-52bbba36efe4" xlink:href="cpix-20221231.xsd#cpix_SubsidiaryInvestmentPaymentsForReturnOfCapital"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NoncontrollingInterestAbstract_5e771935-dac9-4fdc-8eaf-1cd33f0eccd3" xlink:to="loc_cpix_SubsidiaryInvestmentPaymentsForReturnOfCapital_48e52e1b-93ae-48d9-981b-52bbba36efe4" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_ab9efc7f-780c-4b8f-9030-a0459de9373a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MinorityInterestOwnershipPercentageByParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NoncontrollingInterestAbstract_5e771935-dac9-4fdc-8eaf-1cd33f0eccd3" xlink:to="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_ab9efc7f-780c-4b8f-9030-a0459de9373a" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_9fa8574f-3e07-4ccf-8bd2-d584d761ff73" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NoncontrollingInterestAbstract_5e771935-dac9-4fdc-8eaf-1cd33f0eccd3" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_9fa8574f-3e07-4ccf-8bd2-d584d761ff73" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_SharebasedCompensationCharitableContributionofSharesShares_8f1d4e3f-b79a-4c81-abc2-35edcad17002" xlink:href="cpix-20221231.xsd#cpix_SharebasedCompensationCharitableContributionofSharesShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NoncontrollingInterestAbstract_5e771935-dac9-4fdc-8eaf-1cd33f0eccd3" xlink:to="loc_cpix_SharebasedCompensationCharitableContributionofSharesShares_8f1d4e3f-b79a-4c81-abc2-35edcad17002" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_ShareBasedCompensationCharitableContributionOfSharesCommittedCashContributions_99fa45e2-1b51-4949-a340-8350d46e8e2c" xlink:href="cpix-20221231.xsd#cpix_ShareBasedCompensationCharitableContributionOfSharesCommittedCashContributions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NoncontrollingInterestAbstract_5e771935-dac9-4fdc-8eaf-1cd33f0eccd3" xlink:to="loc_cpix_ShareBasedCompensationCharitableContributionOfSharesCommittedCashContributions_99fa45e2-1b51-4949-a340-8350d46e8e2c" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_ShareBasedCompensationCharitableContributionOfSharesCashContributions_08198cf8-173e-485e-88b6-963bd77a9eba" xlink:href="cpix-20221231.xsd#cpix_ShareBasedCompensationCharitableContributionOfSharesCashContributions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NoncontrollingInterestAbstract_5e771935-dac9-4fdc-8eaf-1cd33f0eccd3" xlink:to="loc_cpix_ShareBasedCompensationCharitableContributionOfSharesCashContributions_08198cf8-173e-485e-88b6-963bd77a9eba" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitiesTable_df971cd6-3d72-46b9-9a92-24ac4d80841d" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntitiesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_dei_EntityInformationLineItems_285ffdd9-f89b-4eac-b348-2101ec07dd44" xlink:to="loc_dei_EntitiesTable_df971cd6-3d72-46b9-9a92-24ac4d80841d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_415b9f0e-36f5-43a4-b351-07984bd82ea7" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dei_EntitiesTable_df971cd6-3d72-46b9-9a92-24ac4d80841d" xlink:to="loc_dei_LegalEntityAxis_415b9f0e-36f5-43a4-b351-07984bd82ea7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_415b9f0e-36f5-43a4-b351-07984bd82ea7_default" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_415b9f0e-36f5-43a4-b351-07984bd82ea7" xlink:to="loc_dei_EntityDomain_415b9f0e-36f5-43a4-b351-07984bd82ea7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_5e28d212-51af-4840-aefb-4db6ffa964d0" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_415b9f0e-36f5-43a4-b351-07984bd82ea7" xlink:to="loc_dei_EntityDomain_5e28d212-51af-4840-aefb-4db6ffa964d0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_CumberlandEmergingTechnologiesIncMember_8c6cbbfc-6451-4eaa-a332-f2eb10dc7653" xlink:href="cpix-20221231.xsd#cpix_CumberlandEmergingTechnologiesIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_5e28d212-51af-4840-aefb-4db6ffa964d0" xlink:to="loc_cpix_CumberlandEmergingTechnologiesIncMember_8c6cbbfc-6451-4eaa-a332-f2eb10dc7653" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_560d39e0-8551-454e-a8c0-0e498cd86971" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dei_EntitiesTable_df971cd6-3d72-46b9-9a92-24ac4d80841d" xlink:to="loc_srt_CounterpartyNameAxis_560d39e0-8551-454e-a8c0-0e498cd86971" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_560d39e0-8551-454e-a8c0-0e498cd86971_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_560d39e0-8551-454e-a8c0-0e498cd86971" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_560d39e0-8551-454e-a8c0-0e498cd86971_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_078e820e-d5fe-43ce-8525-b2f3c458e01a" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_560d39e0-8551-454e-a8c0-0e498cd86971" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_078e820e-d5fe-43ce-8525-b2f3c458e01a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_HarbinGloriaPharmaceuticalsCoMember_c49ac435-5569-49e9-be4e-b093c8f7065b" xlink:href="cpix-20221231.xsd#cpix_HarbinGloriaPharmaceuticalsCoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_078e820e-d5fe-43ce-8525-b2f3c458e01a" xlink:to="loc_cpix_HarbinGloriaPharmaceuticalsCoMember_c49ac435-5569-49e9-be4e-b093c8f7065b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_HongKongWinHealthPharmaGroupCoLimitedMember_f241153e-d73d-40a2-b26f-9d3142bf523d" xlink:href="cpix-20221231.xsd#cpix_HongKongWinHealthPharmaGroupCoLimitedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_078e820e-d5fe-43ce-8525-b2f3c458e01a" xlink:to="loc_cpix_HongKongWinHealthPharmaGroupCoLimitedMember_f241153e-d73d-40a2-b26f-9d3142bf523d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_GloriaPharmaceuticalsMember_295c8b28-78ff-445f-8a31-3e0fd9f985d3" xlink:href="cpix-20221231.xsd#cpix_GloriaPharmaceuticalsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_078e820e-d5fe-43ce-8525-b2f3c458e01a" xlink:to="loc_cpix_GloriaPharmaceuticalsMember_295c8b28-78ff-445f-8a31-3e0fd9f985d3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipAxis_2811e01e-cb15-4c18-ba3f-3e0260cb5d63" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_OwnershipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dei_EntitiesTable_df971cd6-3d72-46b9-9a92-24ac4d80841d" xlink:to="loc_srt_OwnershipAxis_2811e01e-cb15-4c18-ba3f-3e0260cb5d63" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_2811e01e-cb15-4c18-ba3f-3e0260cb5d63_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_OwnershipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_OwnershipAxis_2811e01e-cb15-4c18-ba3f-3e0260cb5d63" xlink:to="loc_srt_OwnershipDomain_2811e01e-cb15-4c18-ba3f-3e0260cb5d63_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_663e3ddf-5fff-40a6-b98d-78a30bfb735a" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_OwnershipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_OwnershipAxis_2811e01e-cb15-4c18-ba3f-3e0260cb5d63" xlink:to="loc_srt_OwnershipDomain_663e3ddf-5fff-40a6-b98d-78a30bfb735a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_CumberlandEmergingTechnologiesIncMember_99b0842d-395e-48d2-924a-1fbab34ed441" xlink:href="cpix-20221231.xsd#cpix_CumberlandEmergingTechnologiesIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_663e3ddf-5fff-40a6-b98d-78a30bfb735a" xlink:to="loc_cpix_CumberlandEmergingTechnologiesIncMember_99b0842d-395e-48d2-924a-1fbab34ed441" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cumberlandpharma.com/role/SignificantAccountingPoliciesNarrativeDetails" xlink:type="simple" xlink:href="cpix-20221231.xsd#SignificantAccountingPoliciesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.cumberlandpharma.com/role/SignificantAccountingPoliciesNarrativeDetails" xlink:type="extended" id="i8a6dd82d28514edaae720b691e1f5fd4_SignificantAccountingPoliciesNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasedAssetsLineItems_22267e53-4adf-4b50-a550-116f720b255b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeasedAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingAbstract_d2845f3c-73f2-4b28-b32f-0f98c1825cf2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentReportingAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_22267e53-4adf-4b50-a550-116f720b255b" xlink:to="loc_us-gaap_SegmentReportingAbstract_d2845f3c-73f2-4b28-b32f-0f98c1825cf2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfOperatingSegments_daa6a5cb-0712-4194-be05-660b38c50906" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NumberOfOperatingSegments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingAbstract_d2845f3c-73f2-4b28-b32f-0f98c1825cf2" xlink:to="loc_us-gaap_NumberOfOperatingSegments_daa6a5cb-0712-4194-be05-660b38c50906" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_c69bddca-d1dd-4b3d-9ae5-3ed29ae56a45" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Revenues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingAbstract_d2845f3c-73f2-4b28-b32f-0f98c1825cf2" xlink:to="loc_us-gaap_Revenues_c69bddca-d1dd-4b3d-9ae5-3ed29ae56a45" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_70fbfc46-92ac-4a98-92dc-1466629ea32b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingAbstract_d2845f3c-73f2-4b28-b32f-0f98c1825cf2" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_70fbfc46-92ac-4a98-92dc-1466629ea32b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_StockIssuedDuringPeriodShelfRegistrationProceedsFromSaleofCorporateSecurities_89e9da70-67f4-491a-bfcf-f56d4e2c4288" xlink:href="cpix-20221231.xsd#cpix_StockIssuedDuringPeriodShelfRegistrationProceedsFromSaleofCorporateSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingAbstract_d2845f3c-73f2-4b28-b32f-0f98c1825cf2" xlink:to="loc_cpix_StockIssuedDuringPeriodShelfRegistrationProceedsFromSaleofCorporateSecurities_89e9da70-67f4-491a-bfcf-f56d4e2c4288" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_2668ef8e-0d28-4cf0-8a34-3950ef5eb2e9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GoodwillImpairmentLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingAbstract_d2845f3c-73f2-4b28-b32f-0f98c1825cf2" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_2668ef8e-0d28-4cf0-8a34-3950ef5eb2e9" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsInAffiliatesSubsidiariesAssociatesAndJointVentures_8514901b-0fd3-4012-b950-9180f8f1faae" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentsInAffiliatesSubsidiariesAssociatesAndJointVentures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingAbstract_d2845f3c-73f2-4b28-b32f-0f98c1825cf2" xlink:to="loc_us-gaap_InvestmentsInAffiliatesSubsidiariesAssociatesAndJointVentures_8514901b-0fd3-4012-b950-9180f8f1faae" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_90ee7d59-52d4-486a-919e-9115f09941cc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingAbstract_d2845f3c-73f2-4b28-b32f-0f98c1825cf2" xlink:to="loc_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_90ee7d59-52d4-486a-919e-9115f09941cc" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_78fb3919-45da-4e52-98e0-2a62e68afea2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfOperatingLeasedAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_22267e53-4adf-4b50-a550-116f720b255b" xlink:to="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_78fb3919-45da-4e52-98e0-2a62e68afea2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_7d0fd9b8-37a0-4c3d-9c26-06880b9d98ce" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_78fb3919-45da-4e52-98e0-2a62e68afea2" xlink:to="loc_srt_CounterpartyNameAxis_7d0fd9b8-37a0-4c3d-9c26-06880b9d98ce" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_7d0fd9b8-37a0-4c3d-9c26-06880b9d98ce_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_7d0fd9b8-37a0-4c3d-9c26-06880b9d98ce" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_7d0fd9b8-37a0-4c3d-9c26-06880b9d98ce_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_31e3503d-3f79-443f-b80b-a7d23ff88d7f" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_7d0fd9b8-37a0-4c3d-9c26-06880b9d98ce" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_31e3503d-3f79-443f-b80b-a7d23ff88d7f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_WinHealthInvestmentSingaporeLtdMember_5d6f6446-b174-4a77-a62c-095ce8725af7" xlink:href="cpix-20221231.xsd#cpix_WinHealthInvestmentSingaporeLtdMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_31e3503d-3f79-443f-b80b-a7d23ff88d7f" xlink:to="loc_cpix_WinHealthInvestmentSingaporeLtdMember_5d6f6446-b174-4a77-a62c-095ce8725af7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_dbd40a44-066a-4f5e-a75c-c72177bc25d8" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_78fb3919-45da-4e52-98e0-2a62e68afea2" xlink:to="loc_srt_StatementGeographicalAxis_dbd40a44-066a-4f5e-a75c-c72177bc25d8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_dbd40a44-066a-4f5e-a75c-c72177bc25d8_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_dbd40a44-066a-4f5e-a75c-c72177bc25d8" xlink:to="loc_srt_SegmentGeographicalDomain_dbd40a44-066a-4f5e-a75c-c72177bc25d8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_809453d4-871a-4d80-ac66-1f5338058a5d" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_dbd40a44-066a-4f5e-a75c-c72177bc25d8" xlink:to="loc_srt_SegmentGeographicalDomain_809453d4-871a-4d80-ac66-1f5338058a5d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonUsMember_803f3ca2-f73f-481b-82ab-aa6c958bc10b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NonUsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_809453d4-871a-4d80-ac66-1f5338058a5d" xlink:to="loc_us-gaap_NonUsMember_803f3ca2-f73f-481b-82ab-aa6c958bc10b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_AccountsReceivableAllowancesByComponentAxis_b891f96f-e45c-49e7-bea7-76f2ed837b0e" xlink:href="cpix-20221231.xsd#cpix_AccountsReceivableAllowancesByComponentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_78fb3919-45da-4e52-98e0-2a62e68afea2" xlink:to="loc_cpix_AccountsReceivableAllowancesByComponentAxis_b891f96f-e45c-49e7-bea7-76f2ed837b0e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_AccountsReceivableAllowancesByComponentDomain_b891f96f-e45c-49e7-bea7-76f2ed837b0e_default" xlink:href="cpix-20221231.xsd#cpix_AccountsReceivableAllowancesByComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_cpix_AccountsReceivableAllowancesByComponentAxis_b891f96f-e45c-49e7-bea7-76f2ed837b0e" xlink:to="loc_cpix_AccountsReceivableAllowancesByComponentDomain_b891f96f-e45c-49e7-bea7-76f2ed837b0e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_AccountsReceivableAllowancesByComponentDomain_2807348f-a46c-4fbb-b2a4-67aa58438c40" xlink:href="cpix-20221231.xsd#cpix_AccountsReceivableAllowancesByComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_cpix_AccountsReceivableAllowancesByComponentAxis_b891f96f-e45c-49e7-bea7-76f2ed837b0e" xlink:to="loc_cpix_AccountsReceivableAllowancesByComponentDomain_2807348f-a46c-4fbb-b2a4-67aa58438c40" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_ChargebacksCashDiscountsAndDamagedGoodsMember_84ed6622-2105-4ce1-8fa9-1f333968d3c8" xlink:href="cpix-20221231.xsd#cpix_ChargebacksCashDiscountsAndDamagedGoodsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cpix_AccountsReceivableAllowancesByComponentDomain_2807348f-a46c-4fbb-b2a4-67aa58438c40" xlink:to="loc_cpix_ChargebacksCashDiscountsAndDamagedGoodsMember_84ed6622-2105-4ce1-8fa9-1f333968d3c8" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cumberlandpharma.com/role/SignificantAccountingPoliciesScheduleofIntangibleAssetsUsefulLivesDetails" xlink:type="simple" xlink:href="cpix-20221231.xsd#SignificantAccountingPoliciesScheduleofIntangibleAssetsUsefulLivesDetails"/>
  <link:definitionLink xlink:role="http://www.cumberlandpharma.com/role/SignificantAccountingPoliciesScheduleofIntangibleAssetsUsefulLivesDetails" xlink:type="extended" id="i44adc4d63d9c49a58bd21f8561a016b7_SignificantAccountingPoliciesScheduleofIntangibleAssetsUsefulLivesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_713e393a-5951-4d4a-bcc3-039d9661afb8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_FiniteLivedIntangibleAssetsUsefulLivesTextual_989f8f90-de29-40e6-b40a-1782d89ae5d2" xlink:href="cpix-20221231.xsd#cpix_FiniteLivedIntangibleAssetsUsefulLivesTextual"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_713e393a-5951-4d4a-bcc3-039d9661afb8" xlink:to="loc_cpix_FiniteLivedIntangibleAssetsUsefulLivesTextual_989f8f90-de29-40e6-b40a-1782d89ae5d2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_9539773a-c516-40be-bc22-28ede0a4c71d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_713e393a-5951-4d4a-bcc3-039d9661afb8" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_9539773a-c516-40be-bc22-28ede0a4c71d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_ce400304-fed2-4204-b06b-98a6cc906362" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_9539773a-c516-40be-bc22-28ede0a4c71d" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_ce400304-fed2-4204-b06b-98a6cc906362" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_ce400304-fed2-4204-b06b-98a6cc906362_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_ce400304-fed2-4204-b06b-98a6cc906362" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_ce400304-fed2-4204-b06b-98a6cc906362_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_78b30fb7-c4de-411f-8191-c411afee0fc6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_ce400304-fed2-4204-b06b-98a6cc906362" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_78b30fb7-c4de-411f-8191-c411afee0fc6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_ProductRightsMember_dff38342-c85f-4612-80c7-06c1dde9d1f6" xlink:href="cpix-20221231.xsd#cpix_ProductRightsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_78b30fb7-c4de-411f-8191-c411afee0fc6" xlink:to="loc_cpix_ProductRightsMember_dff38342-c85f-4612-80c7-06c1dde9d1f6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LicensingAgreementsMember_b585589f-0e3e-479a-9334-973133b5a3dd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LicensingAgreementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_78b30fb7-c4de-411f-8191-c411afee0fc6" xlink:to="loc_us-gaap_LicensingAgreementsMember_b585589f-0e3e-479a-9334-973133b5a3dd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PatentsMember_a19900ab-426f-448c-8f59-9746ae433aa7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PatentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_78b30fb7-c4de-411f-8191-c411afee0fc6" xlink:to="loc_us-gaap_PatentsMember_a19900ab-426f-448c-8f59-9746ae433aa7" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cumberlandpharma.com/role/RediTrexVibativandSancusoNarrativeDetails" xlink:type="simple" xlink:href="cpix-20221231.xsd#RediTrexVibativandSancusoNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.cumberlandpharma.com/role/RediTrexVibativandSancusoNarrativeDetails" xlink:type="extended" id="i5cec08827b5140198225893e24df08ec_RediTrexVibativandSancusoNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesGross_dbd053da-cdfa-4670-8a3e-b00b31d3f2a8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireBusinessesGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesGross_dbd053da-cdfa-4670-8a3e-b00b31d3f2a8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferredLiabilitiesIncurred_6949c1af-98bb-4c1d-a85e-5e8d954c8640" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationConsiderationTransferredLiabilitiesIncurred"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferredLiabilitiesIncurred_6949c1af-98bb-4c1d-a85e-5e8d954c8640" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_2bbd8592-679e-4a8b-a0ea-f35f6e3be0d3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesAcquisitions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_2bbd8592-679e-4a8b-a0ea-f35f6e3be0d3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueAcquisitions_e948f306-a752-4209-b63f-b46d1fd3811e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueAcquisitions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueAcquisitions_e948f306-a752-4209-b63f-b46d1fd3811e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_e6c34294-9982-487f-862b-debc309444c8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_e6c34294-9982-487f-862b-debc309444c8" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_CollaborativeArrangementRightsAndObligationsRestrictedSharesReceivable_24cf13bf-37fe-4e75-9ffe-c1cde8920ac5" xlink:href="cpix-20221231.xsd#cpix_CollaborativeArrangementRightsAndObligationsRestrictedSharesReceivable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:to="loc_cpix_CollaborativeArrangementRightsAndObligationsRestrictedSharesReceivable_24cf13bf-37fe-4e75-9ffe-c1cde8920ac5" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_CollaborativeArrangementRightsAndObligationsMilestonePaymentReceivable_9c6e4b8b-4fbb-4d6d-a854-738802b4fef6" xlink:href="cpix-20221231.xsd#cpix_CollaborativeArrangementRightsAndObligationsMilestonePaymentReceivable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:to="loc_cpix_CollaborativeArrangementRightsAndObligationsMilestonePaymentReceivable_9c6e4b8b-4fbb-4d6d-a854-738802b4fef6" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_CollaborativeArrangementRightsAndObligationsMilestonePaymentCreditDue_57220274-97f0-41bc-b6ed-2c706ffdf693" xlink:href="cpix-20221231.xsd#cpix_CollaborativeArrangementRightsAndObligationsMilestonePaymentCreditDue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:to="loc_cpix_CollaborativeArrangementRightsAndObligationsMilestonePaymentCreditDue_57220274-97f0-41bc-b6ed-2c706ffdf693" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_81e68693-323c-4bb5-96e8-c23015a9c2bb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_81e68693-323c-4bb5-96e8-c23015a9c2bb" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_TieredRoyaltyPaymentsPercentage_f8cf0625-fec2-4c36-90fe-9b37d91ac0ae" xlink:href="cpix-20221231.xsd#cpix_TieredRoyaltyPaymentsPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:to="loc_cpix_TieredRoyaltyPaymentsPercentage_f8cf0625-fec2-4c36-90fe-9b37d91ac0ae" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_TieredRoyaltyPaymentsThreshold_7b754664-5e7e-4bae-a475-9fbf93c504cf" xlink:href="cpix-20221231.xsd#cpix_TieredRoyaltyPaymentsThreshold"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:to="loc_cpix_TieredRoyaltyPaymentsThreshold_7b754664-5e7e-4bae-a475-9fbf93c504cf" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_0d7a61c0-4dc4-4b44-889b-81fa96c562b2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_0d7a61c0-4dc4-4b44-889b-81fa96c562b2" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_c50f54b5-d2ff-434d-86ad-681f7ca4d107" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_c50f54b5-d2ff-434d-86ad-681f7ca4d107" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_CollaborativeArrangementRightsAndObligationsUpfrontPayment_b0f007ee-456f-4f98-9e54-b22c17436d2b" xlink:href="cpix-20221231.xsd#cpix_CollaborativeArrangementRightsAndObligationsUpfrontPayment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:to="loc_cpix_CollaborativeArrangementRightsAndObligationsUpfrontPayment_b0f007ee-456f-4f98-9e54-b22c17436d2b" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_CollaborativeArrangementRightsAndObligationsSalesMilestonePaymentsMaximum_0c9247d0-e234-42f5-9606-4703ba093e9f" xlink:href="cpix-20221231.xsd#cpix_CollaborativeArrangementRightsAndObligationsSalesMilestonePaymentsMaximum"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:to="loc_cpix_CollaborativeArrangementRightsAndObligationsSalesMilestonePaymentsMaximum_0c9247d0-e234-42f5-9606-4703ba093e9f" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_CollaborativeArrangementRightsAndObligationsSalesMilestonePaymentsExpected_e369397d-9825-454e-a75c-a692469a6d92" xlink:href="cpix-20221231.xsd#cpix_CollaborativeArrangementRightsAndObligationsSalesMilestonePaymentsExpected"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:to="loc_cpix_CollaborativeArrangementRightsAndObligationsSalesMilestonePaymentsExpected_e369397d-9825-454e-a75c-a692469a6d92" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_CollaborativeArrangementRightsAndObligationsSalesMilestonePaymentsRemaining_ba7028bb-6263-428e-b081-fc1e5720b59e" xlink:href="cpix-20221231.xsd#cpix_CollaborativeArrangementRightsAndObligationsSalesMilestonePaymentsRemaining"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:to="loc_cpix_CollaborativeArrangementRightsAndObligationsSalesMilestonePaymentsRemaining_ba7028bb-6263-428e-b081-fc1e5720b59e" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_CollaborativeArrangementRightsAndObligationsSalesMilestonePaymentsAnnualNetRevenueThreshold_69767a71-a55b-47f1-984e-fea81019861b" xlink:href="cpix-20221231.xsd#cpix_CollaborativeArrangementRightsAndObligationsSalesMilestonePaymentsAnnualNetRevenueThreshold"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:to="loc_cpix_CollaborativeArrangementRightsAndObligationsSalesMilestonePaymentsAnnualNetRevenueThreshold_69767a71-a55b-47f1-984e-fea81019861b" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_CollaborativeArrangementRightsAndObligationsTieredRoyaltyPercent_0c778467-742e-4156-beee-55fe7f1f19ca" xlink:href="cpix-20221231.xsd#cpix_CollaborativeArrangementRightsAndObligationsTieredRoyaltyPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:to="loc_cpix_CollaborativeArrangementRightsAndObligationsTieredRoyaltyPercent_0c778467-742e-4156-beee-55fe7f1f19ca" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets_94dfbcb9-af2a-4b36-9337-4b201b70c95c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets_94dfbcb9-af2a-4b36-9337-4b201b70c95c" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_7253c253-85fa-4fac-bb44-d08ff15b4209" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_7253c253-85fa-4fac-bb44-d08ff15b4209" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_6f36d1d7-cd15-4bd5-8448-bc11bf014e26" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:to="loc_us-gaap_Goodwill_6f36d1d7-cd15-4bd5-8448-bc11bf014e26" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_df41e806-2db9-4db8-9040-afd25bfb9745" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_df41e806-2db9-4db8-9040-afd25bfb9745" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherPaymentsToAcquireBusinesses_827b1d9d-fcb8-4c4d-8571-e1ea0fa21caf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherPaymentsToAcquireBusinesses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:to="loc_us-gaap_OtherPaymentsToAcquireBusinesses_827b1d9d-fcb8-4c4d-8571-e1ea0fa21caf" xlink:type="arc" order="23"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationGoodwillExpectedTaxDeductibleAmount_1a4a22ec-9c62-47a7-9474-6fcd5f971020" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationGoodwillExpectedTaxDeductibleAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:to="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationGoodwillExpectedTaxDeductibleAmount_1a4a22ec-9c62-47a7-9474-6fcd5f971020" xlink:type="arc" order="24"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationProFormaInformationRevenueOfAcquireeSinceAcquisitionDateActual_19a070ac-a932-4571-8a0e-e5ac82d1bfa5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationProFormaInformationRevenueOfAcquireeSinceAcquisitionDateActual"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:to="loc_us-gaap_BusinessCombinationProFormaInformationRevenueOfAcquireeSinceAcquisitionDateActual_19a070ac-a932-4571-8a0e-e5ac82d1bfa5" xlink:type="arc" order="25"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationProFormaInformationEarningsOrLossOfAcquireeSinceAcquisitionDateActual_4f6ea117-cfc7-42da-854d-998a6a42d12d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationProFormaInformationEarningsOrLossOfAcquireeSinceAcquisitionDateActual"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:to="loc_us-gaap_BusinessCombinationProFormaInformationEarningsOrLossOfAcquireeSinceAcquisitionDateActual_4f6ea117-cfc7-42da-854d-998a6a42d12d" xlink:type="arc" order="26"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_958ec7e0-4b2f-467a-a568-63a6f5148208" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7a444bb2-b30f-48df-91e1-3747ed52b866" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_958ec7e0-4b2f-467a-a568-63a6f5148208" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_7e5bc428-4e7c-4319-bfe7-8e4dc4ee301b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_958ec7e0-4b2f-467a-a568-63a6f5148208" xlink:to="loc_us-gaap_AwardTypeAxis_7e5bc428-4e7c-4319-bfe7-8e4dc4ee301b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_7e5bc428-4e7c-4319-bfe7-8e4dc4ee301b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_7e5bc428-4e7c-4319-bfe7-8e4dc4ee301b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_7e5bc428-4e7c-4319-bfe7-8e4dc4ee301b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_48ca72ab-2243-417f-b74e-71b686e79e90" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_7e5bc428-4e7c-4319-bfe7-8e4dc4ee301b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_48ca72ab-2243-417f-b74e-71b686e79e90" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockMember_24a83941-417e-4710-9114-86c8dbd7f822" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_48ca72ab-2243-417f-b74e-71b686e79e90" xlink:to="loc_us-gaap_RestrictedStockMember_24a83941-417e-4710-9114-86c8dbd7f822" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_7887e648-4eb7-4af8-84cf-bc7bf4144b23" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_958ec7e0-4b2f-467a-a568-63a6f5148208" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_7887e648-4eb7-4af8-84cf-bc7bf4144b23" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_7887e648-4eb7-4af8-84cf-bc7bf4144b23_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_7887e648-4eb7-4af8-84cf-bc7bf4144b23" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_7887e648-4eb7-4af8-84cf-bc7bf4144b23_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_d0847b8c-6da6-417c-84e1-8faa70b649bc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_7887e648-4eb7-4af8-84cf-bc7bf4144b23" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_d0847b8c-6da6-417c-84e1-8faa70b649bc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_MethotrexateMember_668c2ff8-babe-4255-b578-aace166f112f" xlink:href="cpix-20221231.xsd#cpix_MethotrexateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_d0847b8c-6da6-417c-84e1-8faa70b649bc" xlink:to="loc_cpix_MethotrexateMember_668c2ff8-babe-4255-b578-aace166f112f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_SancusoMember_437d42f7-46f2-47be-9daf-2dce098b08fb" xlink:href="cpix-20221231.xsd#cpix_SancusoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_d0847b8c-6da6-417c-84e1-8faa70b649bc" xlink:to="loc_cpix_SancusoMember_437d42f7-46f2-47be-9daf-2dce098b08fb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_VIBATIVMember_a40ee1d2-7950-4371-b909-5cb02eec32b3" xlink:href="cpix-20221231.xsd#cpix_VIBATIVMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_d0847b8c-6da6-417c-84e1-8faa70b649bc" xlink:to="loc_cpix_VIBATIVMember_a40ee1d2-7950-4371-b909-5cb02eec32b3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_438cd78a-8e96-442b-a5e7-7650540aba50" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_958ec7e0-4b2f-467a-a568-63a6f5148208" xlink:to="loc_srt_CounterpartyNameAxis_438cd78a-8e96-442b-a5e7-7650540aba50" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_438cd78a-8e96-442b-a5e7-7650540aba50_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_438cd78a-8e96-442b-a5e7-7650540aba50" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_438cd78a-8e96-442b-a5e7-7650540aba50_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_2f6655b7-8246-4bc5-bc98-c07679b8c4cc" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_438cd78a-8e96-442b-a5e7-7650540aba50" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_2f6655b7-8246-4bc5-bc98-c07679b8c4cc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_KyowaKirinMember_8c354878-afa9-46aa-9601-8bd43a49c8e3" xlink:href="cpix-20221231.xsd#cpix_KyowaKirinMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_2f6655b7-8246-4bc5-bc98-c07679b8c4cc" xlink:to="loc_cpix_KyowaKirinMember_8c354878-afa9-46aa-9601-8bd43a49c8e3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_NordicGroupBVMember_abc226aa-e288-49a8-8198-b2174345f0a0" xlink:href="cpix-20221231.xsd#cpix_NordicGroupBVMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_2f6655b7-8246-4bc5-bc98-c07679b8c4cc" xlink:to="loc_cpix_NordicGroupBVMember_abc226aa-e288-49a8-8198-b2174345f0a0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_911c167d-3a27-47a5-a070-dd1076f4a782" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_958ec7e0-4b2f-467a-a568-63a6f5148208" xlink:to="loc_us-gaap_TypeOfArrangementAxis_911c167d-3a27-47a5-a070-dd1076f4a782" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_911c167d-3a27-47a5-a070-dd1076f4a782_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_911c167d-3a27-47a5-a070-dd1076f4a782" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_911c167d-3a27-47a5-a070-dd1076f4a782_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_e4a20501-1a40-48b7-bb2a-f01de04c82f2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_911c167d-3a27-47a5-a070-dd1076f4a782" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_e4a20501-1a40-48b7-bb2a-f01de04c82f2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementTransactionWithPartyToCollaborativeArrangementMember_d0efb8d1-20e5-4dd8-84fd-299d9a31296b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CollaborativeArrangementTransactionWithPartyToCollaborativeArrangementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_e4a20501-1a40-48b7-bb2a-f01de04c82f2" xlink:to="loc_us-gaap_CollaborativeArrangementTransactionWithPartyToCollaborativeArrangementMember_d0efb8d1-20e5-4dd8-84fd-299d9a31296b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_526ea7aa-1e5a-4761-9497-c03078e08fad" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_958ec7e0-4b2f-467a-a568-63a6f5148208" xlink:to="loc_srt_RangeAxis_526ea7aa-1e5a-4761-9497-c03078e08fad" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_526ea7aa-1e5a-4761-9497-c03078e08fad_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_526ea7aa-1e5a-4761-9497-c03078e08fad" xlink:to="loc_srt_RangeMember_526ea7aa-1e5a-4761-9497-c03078e08fad_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_c58ba579-123b-4f8f-a7a0-833d14b45a44" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_526ea7aa-1e5a-4761-9497-c03078e08fad" xlink:to="loc_srt_RangeMember_c58ba579-123b-4f8f-a7a0-833d14b45a44" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_fc752d75-ad62-4800-bbef-3c31043af7a4" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_c58ba579-123b-4f8f-a7a0-833d14b45a44" xlink:to="loc_srt_MaximumMember_fc752d75-ad62-4800-bbef-3c31043af7a4" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cumberlandpharma.com/role/RediTrexVibativandSancusoScheduleofContingentConsiderationandPreliminaryAllocationDetails" xlink:type="simple" xlink:href="cpix-20221231.xsd#RediTrexVibativandSancusoScheduleofContingentConsiderationandPreliminaryAllocationDetails"/>
  <link:definitionLink xlink:role="http://www.cumberlandpharma.com/role/RediTrexVibativandSancusoScheduleofContingentConsiderationandPreliminaryAllocationDetails" xlink:type="extended" id="i76b84af62fa5410c9163199d73a0ca59_RediTrexVibativandSancusoScheduleofContingentConsiderationandPreliminaryAllocationDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_da5d987d-f719-4825-b5c0-0635500b7126" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_18f83fb2-7013-43fe-822c-6d8e1f6ca604" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_da5d987d-f719-4825-b5c0-0635500b7126" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_18f83fb2-7013-43fe-822c-6d8e1f6ca604" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRoyalties_e637d8fd-1858-4092-859c-ab8258cd2ba9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsForRoyalties"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_da5d987d-f719-4825-b5c0-0635500b7126" xlink:to="loc_us-gaap_PaymentsForRoyalties_e637d8fd-1858-4092-859c-ab8258cd2ba9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_4859ff33-8fdc-4ea7-aaac-65e3a6a8495a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_da5d987d-f719-4825-b5c0-0635500b7126" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_4859ff33-8fdc-4ea7-aaac-65e3a6a8495a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_BusinessCombinationContingentConsiderationEarnedAndAccruedInOperatingExpenses_5e975a64-1771-444c-978b-e03a38debdf7" xlink:href="cpix-20221231.xsd#cpix_BusinessCombinationContingentConsiderationEarnedAndAccruedInOperatingExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_da5d987d-f719-4825-b5c0-0635500b7126" xlink:to="loc_cpix_BusinessCombinationContingentConsiderationEarnedAndAccruedInOperatingExpenses_5e975a64-1771-444c-978b-e03a38debdf7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_96bf8620-cc25-4904-90ac-8b4b670bda20" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_c917ed17-276b-4de2-aa84-01e22f089a29" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_da5d987d-f719-4825-b5c0-0635500b7126" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_c917ed17-276b-4de2-aa84-01e22f089a29" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_c5a89b5e-b520-4c5d-8645-dcb481474cc0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_c917ed17-276b-4de2-aa84-01e22f089a29" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_c5a89b5e-b520-4c5d-8645-dcb481474cc0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_c5a89b5e-b520-4c5d-8645-dcb481474cc0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_c5a89b5e-b520-4c5d-8645-dcb481474cc0" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_c5a89b5e-b520-4c5d-8645-dcb481474cc0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_6c74825f-4754-494d-8c89-f43f058d8eae" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_c5a89b5e-b520-4c5d-8645-dcb481474cc0" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_6c74825f-4754-494d-8c89-f43f058d8eae" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_VIBATIVMember_7e449286-178f-41c5-8a3b-51dd923256d8" xlink:href="cpix-20221231.xsd#cpix_VIBATIVMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_6c74825f-4754-494d-8c89-f43f058d8eae" xlink:to="loc_cpix_VIBATIVMember_7e449286-178f-41c5-8a3b-51dd923256d8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_SancusoMember_56231a51-e860-47ef-9488-4b2a9f546dfb" xlink:href="cpix-20221231.xsd#cpix_SancusoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_6c74825f-4754-494d-8c89-f43f058d8eae" xlink:to="loc_cpix_SancusoMember_56231a51-e860-47ef-9488-4b2a9f546dfb" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cumberlandpharma.com/role/RevenuesScheduleofNetProductRevenuesbyProductDetails" xlink:type="simple" xlink:href="cpix-20221231.xsd#RevenuesScheduleofNetProductRevenuesbyProductDetails"/>
  <link:definitionLink xlink:role="http://www.cumberlandpharma.com/role/RevenuesScheduleofNetProductRevenuesbyProductDetails" xlink:type="extended" id="i86e32a24920e4c9fac6cc8c3a0c82004_RevenuesScheduleofNetProductRevenuesbyProductDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_4196cb05-7576-46d9-a9b1-d576776617c6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_691e523d-146a-4d09-81bd-13f1ae604678" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_4196cb05-7576-46d9-a9b1-d576776617c6" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_691e523d-146a-4d09-81bd-13f1ae604678" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable_3d9a88b2-5446-4488-b761-38df2061ed42" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_4196cb05-7576-46d9-a9b1-d576776617c6" xlink:to="loc_us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable_3d9a88b2-5446-4488-b761-38df2061ed42" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_ab6d8a6c-ceee-49f9-a6a9-15a57d854843" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable_3d9a88b2-5446-4488-b761-38df2061ed42" xlink:to="loc_srt_ProductOrServiceAxis_ab6d8a6c-ceee-49f9-a6a9-15a57d854843" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_ab6d8a6c-ceee-49f9-a6a9-15a57d854843_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_ab6d8a6c-ceee-49f9-a6a9-15a57d854843" xlink:to="loc_srt_ProductsAndServicesDomain_ab6d8a6c-ceee-49f9-a6a9-15a57d854843_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_80b260c9-94ca-4629-8202-9a0ab8180273" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_ab6d8a6c-ceee-49f9-a6a9-15a57d854843" xlink:to="loc_srt_ProductsAndServicesDomain_80b260c9-94ca-4629-8202-9a0ab8180273" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_KristaloseMember_6d29844f-8d7c-45ff-863c-7c86185fae5b" xlink:href="cpix-20221231.xsd#cpix_KristaloseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_80b260c9-94ca-4629-8202-9a0ab8180273" xlink:to="loc_cpix_KristaloseMember_6d29844f-8d7c-45ff-863c-7c86185fae5b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_SancusoMember_be048a82-56dc-4dce-9eaa-5a166d035fe1" xlink:href="cpix-20221231.xsd#cpix_SancusoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_80b260c9-94ca-4629-8202-9a0ab8180273" xlink:to="loc_cpix_SancusoMember_be048a82-56dc-4dce-9eaa-5a166d035fe1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_CaldolorMember_32e42f55-1140-4821-8979-b10d4b4b806c" xlink:href="cpix-20221231.xsd#cpix_CaldolorMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_80b260c9-94ca-4629-8202-9a0ab8180273" xlink:to="loc_cpix_CaldolorMember_32e42f55-1140-4821-8979-b10d4b4b806c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_ProductVibativMember_33b839ea-19d6-4dae-8224-14d578e330b4" xlink:href="cpix-20221231.xsd#cpix_ProductVibativMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_80b260c9-94ca-4629-8202-9a0ab8180273" xlink:to="loc_cpix_ProductVibativMember_33b839ea-19d6-4dae-8224-14d578e330b4" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_AcetadoteMember_a6d13afd-642a-4c37-a091-3a9cd2075c52" xlink:href="cpix-20221231.xsd#cpix_AcetadoteMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_80b260c9-94ca-4629-8202-9a0ab8180273" xlink:to="loc_cpix_AcetadoteMember_a6d13afd-642a-4c37-a091-3a9cd2075c52" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_OmeclamoxPakMember_c49ce94c-3ff2-406d-a943-01f52b3c077a" xlink:href="cpix-20221231.xsd#cpix_OmeclamoxPakMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_80b260c9-94ca-4629-8202-9a0ab8180273" xlink:to="loc_cpix_OmeclamoxPakMember_c49ce94c-3ff2-406d-a943-01f52b3c077a" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_VaprisolMember_55a8af66-6bca-4f6c-a62e-715db51b033f" xlink:href="cpix-20221231.xsd#cpix_VaprisolMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_80b260c9-94ca-4629-8202-9a0ab8180273" xlink:to="loc_cpix_VaprisolMember_55a8af66-6bca-4f6c-a62e-715db51b033f" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_RediTrexMember_9af80ad8-1796-44f6-b8b1-8748224a72b4" xlink:href="cpix-20221231.xsd#cpix_RediTrexMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_80b260c9-94ca-4629-8202-9a0ab8180273" xlink:to="loc_cpix_RediTrexMember_9af80ad8-1796-44f6-b8b1-8748224a72b4" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_06a88533-0bcb-4b00-b119-f05af392894f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable_3d9a88b2-5446-4488-b761-38df2061ed42" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_06a88533-0bcb-4b00-b119-f05af392894f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_06a88533-0bcb-4b00-b119-f05af392894f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_06a88533-0bcb-4b00-b119-f05af392894f" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_06a88533-0bcb-4b00-b119-f05af392894f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_aa1a00ab-1676-4258-a655-6ae19c7318c2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_06a88533-0bcb-4b00-b119-f05af392894f" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_aa1a00ab-1676-4258-a655-6ae19c7318c2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_OmeclamoxPakMember_a2d0417a-d89c-44e5-9a10-38c99acadedc" xlink:href="cpix-20221231.xsd#cpix_OmeclamoxPakMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_aa1a00ab-1676-4258-a655-6ae19c7318c2" xlink:to="loc_cpix_OmeclamoxPakMember_a2d0417a-d89c-44e5-9a10-38c99acadedc" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cumberlandpharma.com/role/RevenuesNarrativeDetails" xlink:type="simple" xlink:href="cpix-20221231.xsd#RevenuesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.cumberlandpharma.com/role/RevenuesNarrativeDetails" xlink:type="extended" id="i3425f457f9a1475d9719cee1f470d088_RevenuesNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_aafa6af1-6aa8-439b-bac6-61d27dc9a2e1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_ProductRevenuesAbstract_6888e2bf-a69a-428b-b0f0-de9b4d6a04e1" xlink:href="cpix-20221231.xsd#cpix_ProductRevenuesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_aafa6af1-6aa8-439b-bac6-61d27dc9a2e1" xlink:to="loc_cpix_ProductRevenuesAbstract_6888e2bf-a69a-428b-b0f0-de9b4d6a04e1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_2774cac6-37db-424f-969a-88b6705544ad" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cpix_ProductRevenuesAbstract_6888e2bf-a69a-428b-b0f0-de9b4d6a04e1" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_2774cac6-37db-424f-969a-88b6705544ad" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_OtherRevenuesAbstract_b0dcdbc5-93d2-4d6f-87e7-70a088bd01bc" xlink:href="cpix-20221231.xsd#cpix_OtherRevenuesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_aafa6af1-6aa8-439b-bac6-61d27dc9a2e1" xlink:to="loc_cpix_OtherRevenuesAbstract_b0dcdbc5-93d2-4d6f-87e7-70a088bd01bc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_RevenueRecognitionUpfrontPayment_ff7a6fe6-78c3-4903-98af-0ac5d81a779e" xlink:href="cpix-20221231.xsd#cpix_RevenueRecognitionUpfrontPayment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cpix_OtherRevenuesAbstract_b0dcdbc5-93d2-4d6f-87e7-70a088bd01bc" xlink:to="loc_cpix_RevenueRecognitionUpfrontPayment_ff7a6fe6-78c3-4903-98af-0ac5d81a779e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_RevenueRecognitionPotentialUpfrontPaymentsRelatedtoRegulatoryApproval_643ea9c4-7f7f-4504-9eab-a1269693798c" xlink:href="cpix-20221231.xsd#cpix_RevenueRecognitionPotentialUpfrontPaymentsRelatedtoRegulatoryApproval"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cpix_OtherRevenuesAbstract_b0dcdbc5-93d2-4d6f-87e7-70a088bd01bc" xlink:to="loc_cpix_RevenueRecognitionPotentialUpfrontPaymentsRelatedtoRegulatoryApproval_643ea9c4-7f7f-4504-9eab-a1269693798c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_RevenueRecognitionPotentialUpfrontPaymentRelatedtoProductSales_2cc1fb6c-409d-431a-a3c7-d09db051124e" xlink:href="cpix-20221231.xsd#cpix_RevenueRecognitionPotentialUpfrontPaymentRelatedtoProductSales"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cpix_OtherRevenuesAbstract_b0dcdbc5-93d2-4d6f-87e7-70a088bd01bc" xlink:to="loc_cpix_RevenueRecognitionPotentialUpfrontPaymentRelatedtoProductSales_2cc1fb6c-409d-431a-a3c7-d09db051124e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_RevenueRecognitionCumulativeUpfrontPayment_38bf98e8-3a86-4ba5-bb56-c29a9453e8aa" xlink:href="cpix-20221231.xsd#cpix_RevenueRecognitionCumulativeUpfrontPayment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cpix_OtherRevenuesAbstract_b0dcdbc5-93d2-4d6f-87e7-70a088bd01bc" xlink:to="loc_cpix_RevenueRecognitionCumulativeUpfrontPayment_38bf98e8-3a86-4ba5-bb56-c29a9453e8aa" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_RevenueRecognitionMilestonePayments_00719341-9052-466f-9173-3bed3edbd5b6" xlink:href="cpix-20221231.xsd#cpix_RevenueRecognitionMilestonePayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cpix_OtherRevenuesAbstract_b0dcdbc5-93d2-4d6f-87e7-70a088bd01bc" xlink:to="loc_cpix_RevenueRecognitionMilestonePayments_00719341-9052-466f-9173-3bed3edbd5b6" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable_e77afff5-de10-4f42-bb8c-19a2f77a9d7e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_aafa6af1-6aa8-439b-bac6-61d27dc9a2e1" xlink:to="loc_us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable_e77afff5-de10-4f42-bb8c-19a2f77a9d7e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_624d2a6d-ef0d-44e6-bce7-03341a51d49f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable_e77afff5-de10-4f42-bb8c-19a2f77a9d7e" xlink:to="loc_us-gaap_TypeOfArrangementAxis_624d2a6d-ef0d-44e6-bce7-03341a51d49f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_624d2a6d-ef0d-44e6-bce7-03341a51d49f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_624d2a6d-ef0d-44e6-bce7-03341a51d49f" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_624d2a6d-ef0d-44e6-bce7-03341a51d49f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_691971ae-8699-4e1c-810f-79252ad686b0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_624d2a6d-ef0d-44e6-bce7-03341a51d49f" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_691971ae-8699-4e1c-810f-79252ad686b0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_CollaborativeArrangementFederalSmallBusinessGrantProgramsMember_f2ef6a18-85b1-4329-ba9e-111053c9fc65" xlink:href="cpix-20221231.xsd#cpix_CollaborativeArrangementFederalSmallBusinessGrantProgramsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_691971ae-8699-4e1c-810f-79252ad686b0" xlink:to="loc_cpix_CollaborativeArrangementFederalSmallBusinessGrantProgramsMember_f2ef6a18-85b1-4329-ba9e-111053c9fc65" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_80c80745-763b-4b6d-9350-3f1e18569272" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable_e77afff5-de10-4f42-bb8c-19a2f77a9d7e" xlink:to="loc_srt_ProductOrServiceAxis_80c80745-763b-4b6d-9350-3f1e18569272" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_80c80745-763b-4b6d-9350-3f1e18569272_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_80c80745-763b-4b6d-9350-3f1e18569272" xlink:to="loc_srt_ProductsAndServicesDomain_80c80745-763b-4b6d-9350-3f1e18569272_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_9d8bbf2f-af54-4cb6-b24f-00010da3fdcc" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_80c80745-763b-4b6d-9350-3f1e18569272" xlink:to="loc_srt_ProductsAndServicesDomain_9d8bbf2f-af54-4cb6-b24f-00010da3fdcc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrantMember_5f8cf489-7ee0-4d53-a851-3fd18fe80926" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_9d8bbf2f-af54-4cb6-b24f-00010da3fdcc" xlink:to="loc_us-gaap_GrantMember_5f8cf489-7ee0-4d53-a851-3fd18fe80926" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cumberlandpharma.com/role/InventoriesNarrativeDetails" xlink:type="simple" xlink:href="cpix-20221231.xsd#InventoriesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.cumberlandpharma.com/role/InventoriesNarrativeDetails" xlink:type="extended" id="i38d6c6b592ec430db50d5e709875eee1_InventoriesNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryLineItems_38c4e80d-d931-4abf-a7a5-ac6b4dba03ec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryValuationReserves_7803801c-0986-4c86-86ab-2dd180b6ad54" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryValuationReserves"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryLineItems_38c4e80d-d931-4abf-a7a5-ac6b4dba03ec" xlink:to="loc_us-gaap_InventoryValuationReserves_7803801c-0986-4c86-86ab-2dd180b6ad54" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNoncurrent_4f82e99d-8116-4d00-a84f-5cdde10093af" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryLineItems_38c4e80d-d931-4abf-a7a5-ac6b4dba03ec" xlink:to="loc_us-gaap_InventoryNoncurrent_4f82e99d-8116-4d00-a84f-5cdde10093af" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_a1545177-e16e-4c79-99e2-f899bb7a4900" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryLineItems_38c4e80d-d931-4abf-a7a5-ac6b4dba03ec" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_a1545177-e16e-4c79-99e2-f899bb7a4900" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryCurrentTable_88c6e94b-ff90-426f-95e1-abbd22942f06" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryCurrentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_InventoryLineItems_38c4e80d-d931-4abf-a7a5-ac6b4dba03ec" xlink:to="loc_us-gaap_InventoryCurrentTable_88c6e94b-ff90-426f-95e1-abbd22942f06" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_f02fa9e7-bde1-4f71-86ce-48611b121515" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_InventoryCurrentTable_88c6e94b-ff90-426f-95e1-abbd22942f06" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_f02fa9e7-bde1-4f71-86ce-48611b121515" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_f02fa9e7-bde1-4f71-86ce-48611b121515_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_f02fa9e7-bde1-4f71-86ce-48611b121515" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_f02fa9e7-bde1-4f71-86ce-48611b121515_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_5d1c94ec-cd59-4f47-94ea-997e21b9c920" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_f02fa9e7-bde1-4f71-86ce-48611b121515" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_5d1c94ec-cd59-4f47-94ea-997e21b9c920" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_VIBATIVMember_064ec467-f0f4-49de-92f5-599e5da1f5bd" xlink:href="cpix-20221231.xsd#cpix_VIBATIVMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_5d1c94ec-cd59-4f47-94ea-997e21b9c920" xlink:to="loc_cpix_VIBATIVMember_064ec467-f0f4-49de-92f5-599e5da1f5bd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PublicUtilitiesInventoryAxis_db6efddb-0187-49a0-838b-9444a85738e0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PublicUtilitiesInventoryAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_InventoryCurrentTable_88c6e94b-ff90-426f-95e1-abbd22942f06" xlink:to="loc_us-gaap_PublicUtilitiesInventoryAxis_db6efddb-0187-49a0-838b-9444a85738e0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PublicUtilitiesInventoryTypeDomain_db6efddb-0187-49a0-838b-9444a85738e0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PublicUtilitiesInventoryTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PublicUtilitiesInventoryAxis_db6efddb-0187-49a0-838b-9444a85738e0" xlink:to="loc_us-gaap_PublicUtilitiesInventoryTypeDomain_db6efddb-0187-49a0-838b-9444a85738e0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PublicUtilitiesInventoryTypeDomain_6e5c6b6a-fe52-4531-b60e-a4b25339fd4d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PublicUtilitiesInventoryTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PublicUtilitiesInventoryAxis_db6efddb-0187-49a0-838b-9444a85738e0" xlink:to="loc_us-gaap_PublicUtilitiesInventoryTypeDomain_6e5c6b6a-fe52-4531-b60e-a4b25339fd4d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_IfetrobanClinicalMember_fa064d59-f0cb-4723-bb4a-3e9bd8e27a14" xlink:href="cpix-20221231.xsd#cpix_IfetrobanClinicalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PublicUtilitiesInventoryTypeDomain_6e5c6b6a-fe52-4531-b60e-a4b25339fd4d" xlink:to="loc_cpix_IfetrobanClinicalMember_fa064d59-f0cb-4723-bb4a-3e9bd8e27a14" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_WorkInProcessMember_493bbfc3-ad5f-41d4-ab18-9f91bae57a54" xlink:href="cpix-20221231.xsd#cpix_WorkInProcessMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PublicUtilitiesInventoryTypeDomain_6e5c6b6a-fe52-4531-b60e-a4b25339fd4d" xlink:to="loc_cpix_WorkInProcessMember_493bbfc3-ad5f-41d4-ab18-9f91bae57a54" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cumberlandpharma.com/role/PropertyandEquipmentScheduleofPropertyandEquipmentDetails" xlink:type="simple" xlink:href="cpix-20221231.xsd#PropertyandEquipmentScheduleofPropertyandEquipmentDetails"/>
  <link:definitionLink xlink:role="http://www.cumberlandpharma.com/role/PropertyandEquipmentScheduleofPropertyandEquipmentDetails" xlink:type="extended" id="i00261e6c50134394bbca172b249999db_PropertyandEquipmentScheduleofPropertyandEquipmentDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_e567df7c-0e02-405b-b117-d1a44a9ef322" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_b2d49674-294a-4800-bce0-0835e60d4a6e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_e567df7c-0e02-405b-b117-d1a44a9ef322" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_b2d49674-294a-4800-bce0-0835e60d4a6e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_74d8e9bb-4a3b-40eb-9a34-bf1cfc761254" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_e567df7c-0e02-405b-b117-d1a44a9ef322" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_74d8e9bb-4a3b-40eb-9a34-bf1cfc761254" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_9420a611-8639-4478-a311-48c6e4cacd0f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_e567df7c-0e02-405b-b117-d1a44a9ef322" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_9420a611-8639-4478-a311-48c6e4cacd0f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_5e65c831-14fd-49b2-928f-5ecfc61b9e03" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_e567df7c-0e02-405b-b117-d1a44a9ef322" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_5e65c831-14fd-49b2-928f-5ecfc61b9e03" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_61ccdeed-e0c6-4e69-b8df-59071c23d709" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_e567df7c-0e02-405b-b117-d1a44a9ef322" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_61ccdeed-e0c6-4e69-b8df-59071c23d709" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_47fce53e-2a91-4a7c-9f12-b917870eca57" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_61ccdeed-e0c6-4e69-b8df-59071c23d709" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_47fce53e-2a91-4a7c-9f12-b917870eca57" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_47fce53e-2a91-4a7c-9f12-b917870eca57_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_47fce53e-2a91-4a7c-9f12-b917870eca57" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_47fce53e-2a91-4a7c-9f12-b917870eca57_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ca4c2bc5-d039-4850-85dd-c0acc9f17ea4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_47fce53e-2a91-4a7c-9f12-b917870eca57" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ca4c2bc5-d039-4850-85dd-c0acc9f17ea4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComputerEquipmentMember_d5cf1422-3051-4718-9e98-74bc5f343d4d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComputerEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ca4c2bc5-d039-4850-85dd-c0acc9f17ea4" xlink:to="loc_us-gaap_ComputerEquipmentMember_d5cf1422-3051-4718-9e98-74bc5f343d4d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OfficeEquipmentMember_305caba9-3134-4348-a00b-7a735cf66fd1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OfficeEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ca4c2bc5-d039-4850-85dd-c0acc9f17ea4" xlink:to="loc_us-gaap_OfficeEquipmentMember_305caba9-3134-4348-a00b-7a735cf66fd1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_50a6e6c6-c90f-4a63-be93-db064be74994" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FurnitureAndFixturesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ca4c2bc5-d039-4850-85dd-c0acc9f17ea4" xlink:to="loc_us-gaap_FurnitureAndFixturesMember_50a6e6c6-c90f-4a63-be93-db064be74994" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_96cd5bca-7c3e-4b89-8325-0e2fbfd1e50d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseholdImprovementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ca4c2bc5-d039-4850-85dd-c0acc9f17ea4" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_96cd5bca-7c3e-4b89-8325-0e2fbfd1e50d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_e0107e4e-a8d3-4ad4-a51d-48869e88dd29" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_61ccdeed-e0c6-4e69-b8df-59071c23d709" xlink:to="loc_srt_RangeAxis_e0107e4e-a8d3-4ad4-a51d-48869e88dd29" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_e0107e4e-a8d3-4ad4-a51d-48869e88dd29_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_e0107e4e-a8d3-4ad4-a51d-48869e88dd29" xlink:to="loc_srt_RangeMember_e0107e4e-a8d3-4ad4-a51d-48869e88dd29_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_c72c2b6a-2f6a-438f-bbdc-5338ccf490c9" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_e0107e4e-a8d3-4ad4-a51d-48869e88dd29" xlink:to="loc_srt_RangeMember_c72c2b6a-2f6a-438f-bbdc-5338ccf490c9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_1e0c6970-d18b-4107-9fb3-383668acf335" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_c72c2b6a-2f6a-438f-bbdc-5338ccf490c9" xlink:to="loc_srt_MinimumMember_1e0c6970-d18b-4107-9fb3-383668acf335" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_758d836c-4671-4908-99d6-8b8bac9cadb8" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_c72c2b6a-2f6a-438f-bbdc-5338ccf490c9" xlink:to="loc_srt_MaximumMember_758d836c-4671-4908-99d6-8b8bac9cadb8" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cumberlandpharma.com/role/IntangibleAssetsandGoodwillScheduleofIntangibleAssetsDetails" xlink:type="simple" xlink:href="cpix-20221231.xsd#IntangibleAssetsandGoodwillScheduleofIntangibleAssetsDetails"/>
  <link:definitionLink xlink:role="http://www.cumberlandpharma.com/role/IntangibleAssetsandGoodwillScheduleofIntangibleAssetsDetails" xlink:type="extended" id="iaaeccafd1e7b4c3dbf1fe5e303cb5616_IntangibleAssetsandGoodwillScheduleofIntangibleAssetsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_3ce7456d-50cb-4132-acc0-42a8254b3d38" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_184c9705-2929-4fbf-8869-d3975e33b225" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_3ce7456d-50cb-4132-acc0-42a8254b3d38" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_184c9705-2929-4fbf-8869-d3975e33b225" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_20fee987-60cc-438c-948b-7a21549894f4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_3ce7456d-50cb-4132-acc0-42a8254b3d38" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_20fee987-60cc-438c-948b-7a21549894f4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_08baf4a9-4291-4a7f-b7e8-378d69644944" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_3ce7456d-50cb-4132-acc0-42a8254b3d38" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_08baf4a9-4291-4a7f-b7e8-378d69644944" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_ef1914bc-1919-400e-b371-06690ba37165" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_3ce7456d-50cb-4132-acc0-42a8254b3d38" xlink:to="loc_us-gaap_Goodwill_ef1914bc-1919-400e-b371-06690ba37165" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_7add3059-7362-4ac3-8766-c06b3fc0d5f2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_3ce7456d-50cb-4132-acc0-42a8254b3d38" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_7add3059-7362-4ac3-8766-c06b3fc0d5f2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_cc63a7f1-8ddd-4cca-846e-be537d9fe34b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_7add3059-7362-4ac3-8766-c06b3fc0d5f2" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_cc63a7f1-8ddd-4cca-846e-be537d9fe34b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_cc63a7f1-8ddd-4cca-846e-be537d9fe34b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_cc63a7f1-8ddd-4cca-846e-be537d9fe34b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_cc63a7f1-8ddd-4cca-846e-be537d9fe34b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_fe732015-1e67-4e29-9bd4-c8f3e2497b5b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_cc63a7f1-8ddd-4cca-846e-be537d9fe34b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_fe732015-1e67-4e29-9bd4-c8f3e2497b5b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_ProductAndLicenseRightsMember_71a11a2c-02c2-4834-b2f9-b3cb4698ce22" xlink:href="cpix-20221231.xsd#cpix_ProductAndLicenseRightsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_fe732015-1e67-4e29-9bd4-c8f3e2497b5b" xlink:to="loc_cpix_ProductAndLicenseRightsMember_71a11a2c-02c2-4834-b2f9-b3cb4698ce22" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PatentsMember_5e8210d4-3a87-4f8d-90d5-57172d589732" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PatentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_fe732015-1e67-4e29-9bd4-c8f3e2497b5b" xlink:to="loc_us-gaap_PatentsMember_5e8210d4-3a87-4f8d-90d5-57172d589732" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TrademarksMember_c0104079-d4f2-4b3e-b9fa-41962288c21c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TrademarksMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_fe732015-1e67-4e29-9bd4-c8f3e2497b5b" xlink:to="loc_us-gaap_TrademarksMember_c0104079-d4f2-4b3e-b9fa-41962288c21c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_0aaa7728-0ed4-45b7-8eba-531f3662ed62" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_7add3059-7362-4ac3-8766-c06b3fc0d5f2" xlink:to="loc_srt_ProductOrServiceAxis_0aaa7728-0ed4-45b7-8eba-531f3662ed62" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_0aaa7728-0ed4-45b7-8eba-531f3662ed62_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_0aaa7728-0ed4-45b7-8eba-531f3662ed62" xlink:to="loc_srt_ProductsAndServicesDomain_0aaa7728-0ed4-45b7-8eba-531f3662ed62_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_8febc1b1-7a1f-4fe0-b088-478925cc4bfa" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_0aaa7728-0ed4-45b7-8eba-531f3662ed62" xlink:to="loc_srt_ProductsAndServicesDomain_8febc1b1-7a1f-4fe0-b088-478925cc4bfa" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_KristaloseMember_53eaea24-de93-418a-a5cc-4c2d0423dd15" xlink:href="cpix-20221231.xsd#cpix_KristaloseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_8febc1b1-7a1f-4fe0-b088-478925cc4bfa" xlink:to="loc_cpix_KristaloseMember_53eaea24-de93-418a-a5cc-4c2d0423dd15" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cumberlandpharma.com/role/IntangibleAssetsandGoodwillNarrativeDetails" xlink:type="simple" xlink:href="cpix-20221231.xsd#IntangibleAssetsandGoodwillNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.cumberlandpharma.com/role/IntangibleAssetsandGoodwillNarrativeDetails" xlink:type="extended" id="i7a4940c3139c439f99d6520bbb65cc92_IntangibleAssetsandGoodwillNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems_202e4762-b975-4616-8f9b-c0bd8c5bdd2b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireIntangibleAssets_8be2394a-b54a-4b1d-9ada-14a617e33500" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireIntangibleAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems_202e4762-b975-4616-8f9b-c0bd8c5bdd2b" xlink:to="loc_us-gaap_PaymentsToAcquireIntangibleAssets_8be2394a-b54a-4b1d-9ada-14a617e33500" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_2c1c12b4-d369-46d2-8e50-e5d1f6360784" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems_202e4762-b975-4616-8f9b-c0bd8c5bdd2b" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_2c1c12b4-d369-46d2-8e50-e5d1f6360784" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_1843f6ee-9ed9-4309-be3b-761e9efa2e11" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems_202e4762-b975-4616-8f9b-c0bd8c5bdd2b" xlink:to="loc_us-gaap_Goodwill_1843f6ee-9ed9-4309-be3b-761e9efa2e11" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_52b905ac-3c91-4dd4-8c0b-55848aea7f48" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems_202e4762-b975-4616-8f9b-c0bd8c5bdd2b" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_52b905ac-3c91-4dd4-8c0b-55848aea7f48" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_f9111b8c-2497-4990-9518-5830e3bebe0f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_52b905ac-3c91-4dd4-8c0b-55848aea7f48" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_f9111b8c-2497-4990-9518-5830e3bebe0f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_f9111b8c-2497-4990-9518-5830e3bebe0f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_f9111b8c-2497-4990-9518-5830e3bebe0f" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_f9111b8c-2497-4990-9518-5830e3bebe0f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_4e2a3595-67ae-4f2d-85c4-950f9f9d611a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_f9111b8c-2497-4990-9518-5830e3bebe0f" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_4e2a3595-67ae-4f2d-85c4-950f9f9d611a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PatentsMember_1c0f96e0-a487-4e26-b0c9-ccd57560024e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PatentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_4e2a3595-67ae-4f2d-85c4-950f9f9d611a" xlink:to="loc_us-gaap_PatentsMember_1c0f96e0-a487-4e26-b0c9-ccd57560024e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_4417cb20-0690-4325-b312-d3f0b378b706" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_52b905ac-3c91-4dd4-8c0b-55848aea7f48" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_4417cb20-0690-4325-b312-d3f0b378b706" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_4417cb20-0690-4325-b312-d3f0b378b706_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_4417cb20-0690-4325-b312-d3f0b378b706" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_4417cb20-0690-4325-b312-d3f0b378b706_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_11f311e9-43cf-4bdb-9bd5-c23568f58ebf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_4417cb20-0690-4325-b312-d3f0b378b706" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_11f311e9-43cf-4bdb-9bd5-c23568f58ebf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_SancusoMember_2bc6c292-cb3f-46c1-9dec-af46aa1a5be4" xlink:href="cpix-20221231.xsd#cpix_SancusoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_11f311e9-43cf-4bdb-9bd5-c23568f58ebf" xlink:to="loc_cpix_SancusoMember_2bc6c292-cb3f-46c1-9dec-af46aa1a5be4" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cumberlandpharma.com/role/DebtLineofCreditDetails" xlink:type="simple" xlink:href="cpix-20221231.xsd#DebtLineofCreditDetails"/>
  <link:definitionLink xlink:role="http://www.cumberlandpharma.com/role/DebtLineofCreditDetails" xlink:type="extended" id="i9a294a2b253b45e28513791fe1dfdb50_DebtLineofCreditDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityLineItems_82be1a6f-ec8a-4c03-a1d6-a272ec38b490" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_LineOfCreditFacilityAdditionalBorrowingCapacity_9b9ba369-9e46-44aa-bcf1-fbfa41cae49f" xlink:href="cpix-20221231.xsd#cpix_LineOfCreditFacilityAdditionalBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_82be1a6f-ec8a-4c03-a1d6-a272ec38b490" xlink:to="loc_cpix_LineOfCreditFacilityAdditionalBorrowingCapacity_9b9ba369-9e46-44aa-bcf1-fbfa41cae49f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityCurrentBorrowingCapacity_5a7ad91c-95df-437a-8c4a-ed108765bcfd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityCurrentBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_82be1a6f-ec8a-4c03-a1d6-a272ec38b490" xlink:to="loc_us-gaap_LineOfCreditFacilityCurrentBorrowingCapacity_5a7ad91c-95df-437a-8c4a-ed108765bcfd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_DebtInstrumentCovenantUnrestrictedCashThreshold_4788879d-500a-4c83-8f56-a0794ff9cd55" xlink:href="cpix-20221231.xsd#cpix_DebtInstrumentCovenantUnrestrictedCashThreshold"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_82be1a6f-ec8a-4c03-a1d6-a272ec38b490" xlink:to="loc_cpix_DebtInstrumentCovenantUnrestrictedCashThreshold_4788879d-500a-4c83-8f56-a0794ff9cd55" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermLineOfCredit_594f9b75-3a21-4e0b-8eb8-fa3ae5b93179" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermLineOfCredit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_82be1a6f-ec8a-4c03-a1d6-a272ec38b490" xlink:to="loc_us-gaap_LongTermLineOfCredit_594f9b75-3a21-4e0b-8eb8-fa3ae5b93179" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_de7e8447-4fed-45c0-b1fd-9d9df9f584a9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_82be1a6f-ec8a-4c03-a1d6-a272ec38b490" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_de7e8447-4fed-45c0-b1fd-9d9df9f584a9" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityUnusedCapacityCommitmentFeePercentage_40cb8582-ac15-4f77-948d-2dcb6b18371f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityUnusedCapacityCommitmentFeePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_82be1a6f-ec8a-4c03-a1d6-a272ec38b490" xlink:to="loc_us-gaap_LineOfCreditFacilityUnusedCapacityCommitmentFeePercentage_40cb8582-ac15-4f77-948d-2dcb6b18371f" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_TheCoronavirusAidReliefAndEconomicSecurityActLoanProceedsReceived_3fc05b37-adf1-4a7b-8450-d4920d4a42de" xlink:href="cpix-20221231.xsd#cpix_TheCoronavirusAidReliefAndEconomicSecurityActLoanProceedsReceived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_82be1a6f-ec8a-4c03-a1d6-a272ec38b490" xlink:to="loc_cpix_TheCoronavirusAidReliefAndEconomicSecurityActLoanProceedsReceived_3fc05b37-adf1-4a7b-8450-d4920d4a42de" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityTable_5f901001-9b71-4d86-9445-3c60cdbaced2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_82be1a6f-ec8a-4c03-a1d6-a272ec38b490" xlink:to="loc_us-gaap_LineOfCreditFacilityTable_5f901001-9b71-4d86-9445-3c60cdbaced2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityAxis_8e35ec77-0d4c-417f-9fea-c5325a843173" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CreditFacilityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LineOfCreditFacilityTable_5f901001-9b71-4d86-9445-3c60cdbaced2" xlink:to="loc_us-gaap_CreditFacilityAxis_8e35ec77-0d4c-417f-9fea-c5325a843173" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_8e35ec77-0d4c-417f-9fea-c5325a843173_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CreditFacilityAxis_8e35ec77-0d4c-417f-9fea-c5325a843173" xlink:to="loc_us-gaap_CreditFacilityDomain_8e35ec77-0d4c-417f-9fea-c5325a843173_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_6e14c12a-b2dd-4215-9316-a851c5443692" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CreditFacilityAxis_8e35ec77-0d4c-417f-9fea-c5325a843173" xlink:to="loc_us-gaap_CreditFacilityDomain_6e14c12a-b2dd-4215-9316-a851c5443692" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_898f4a89-7580-4a6c-8d64-0f51f199ea03" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_6e14c12a-b2dd-4215-9316-a851c5443692" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_898f4a89-7580-4a6c-8d64-0f51f199ea03" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityAxis_d41cb82c-5c88-4b5a-8d59-09f3db7622cd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LineOfCreditFacilityTable_5f901001-9b71-4d86-9445-3c60cdbaced2" xlink:to="loc_us-gaap_LineOfCreditFacilityAxis_d41cb82c-5c88-4b5a-8d59-09f3db7622cd" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityLenderDomain_d41cb82c-5c88-4b5a-8d59-09f3db7622cd_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityLenderDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LineOfCreditFacilityAxis_d41cb82c-5c88-4b5a-8d59-09f3db7622cd" xlink:to="loc_us-gaap_LineOfCreditFacilityLenderDomain_d41cb82c-5c88-4b5a-8d59-09f3db7622cd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityLenderDomain_0d4020df-1623-423d-8ad3-83ee25765ce6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityLenderDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LineOfCreditFacilityAxis_d41cb82c-5c88-4b5a-8d59-09f3db7622cd" xlink:to="loc_us-gaap_LineOfCreditFacilityLenderDomain_0d4020df-1623-423d-8ad3-83ee25765ce6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_PinnacleBankMember_363249ef-d542-4312-85ec-5325ac7b61ea" xlink:href="cpix-20221231.xsd#cpix_PinnacleBankMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_0d4020df-1623-423d-8ad3-83ee25765ce6" xlink:to="loc_cpix_PinnacleBankMember_363249ef-d542-4312-85ec-5325ac7b61ea" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_33bde9ca-bdcc-4d53-8d4f-b21c76bc75d6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LineOfCreditFacilityTable_5f901001-9b71-4d86-9445-3c60cdbaced2" xlink:to="loc_us-gaap_DebtInstrumentAxis_33bde9ca-bdcc-4d53-8d4f-b21c76bc75d6" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_33bde9ca-bdcc-4d53-8d4f-b21c76bc75d6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_33bde9ca-bdcc-4d53-8d4f-b21c76bc75d6" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_33bde9ca-bdcc-4d53-8d4f-b21c76bc75d6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_88049202-1dcc-4ca2-b7bc-cf1f93e06efd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_33bde9ca-bdcc-4d53-8d4f-b21c76bc75d6" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_88049202-1dcc-4ca2-b7bc-cf1f93e06efd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_FifthAmendmentMember_35f35056-f6bf-4a80-b41c-50017f731213" xlink:href="cpix-20221231.xsd#cpix_FifthAmendmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_88049202-1dcc-4ca2-b7bc-cf1f93e06efd" xlink:to="loc_cpix_FifthAmendmentMember_35f35056-f6bf-4a80-b41c-50017f731213" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_SecondAmendmentMember_6d45f067-282f-4dc4-8941-b578557292a0" xlink:href="cpix-20221231.xsd#cpix_SecondAmendmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_88049202-1dcc-4ca2-b7bc-cf1f93e06efd" xlink:to="loc_cpix_SecondAmendmentMember_6d45f067-282f-4dc4-8941-b578557292a0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditMember_13c6ed82-e3ae-4b83-a479-8d4c5644fa84" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_88049202-1dcc-4ca2-b7bc-cf1f93e06efd" xlink:to="loc_us-gaap_LineOfCreditMember_13c6ed82-e3ae-4b83-a479-8d4c5644fa84" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_PaymentProtectionProgramMember_dca36c5a-528a-4b7f-8e8b-6ecf47f5ba4b" xlink:href="cpix-20221231.xsd#cpix_PaymentProtectionProgramMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_88049202-1dcc-4ca2-b7bc-cf1f93e06efd" xlink:to="loc_cpix_PaymentProtectionProgramMember_dca36c5a-528a-4b7f-8e8b-6ecf47f5ba4b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_NinthAmemdmentMember_e1191c6f-49aa-4f14-8ce8-0ab0149e546e" xlink:href="cpix-20221231.xsd#cpix_NinthAmemdmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_88049202-1dcc-4ca2-b7bc-cf1f93e06efd" xlink:to="loc_cpix_NinthAmemdmentMember_e1191c6f-49aa-4f14-8ce8-0ab0149e546e" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_b31a1883-7fca-435e-8e54-17a14cc0c866" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LineOfCreditFacilityTable_5f901001-9b71-4d86-9445-3c60cdbaced2" xlink:to="loc_srt_RangeAxis_b31a1883-7fca-435e-8e54-17a14cc0c866" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_b31a1883-7fca-435e-8e54-17a14cc0c866_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_b31a1883-7fca-435e-8e54-17a14cc0c866" xlink:to="loc_srt_RangeMember_b31a1883-7fca-435e-8e54-17a14cc0c866_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_643fd113-a3ce-4984-a645-cf465d04d8e3" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_b31a1883-7fca-435e-8e54-17a14cc0c866" xlink:to="loc_srt_RangeMember_643fd113-a3ce-4984-a645-cf465d04d8e3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_44a2b465-8975-4d7b-9c92-661d5ba3f6f8" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_643fd113-a3ce-4984-a645-cf465d04d8e3" xlink:to="loc_srt_MinimumMember_44a2b465-8975-4d7b-9c92-661d5ba3f6f8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_b289b7b9-7f06-4734-ab1b-ca2b38722896" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_643fd113-a3ce-4984-a645-cf465d04d8e3" xlink:to="loc_srt_MaximumMember_b289b7b9-7f06-4734-ab1b-ca2b38722896" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_5a655251-d0e1-452f-96dd-698e4dbf83bf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LineOfCreditFacilityTable_5f901001-9b71-4d86-9445-3c60cdbaced2" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_5a655251-d0e1-452f-96dd-698e4dbf83bf" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_5a655251-d0e1-452f-96dd-698e4dbf83bf_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_5a655251-d0e1-452f-96dd-698e4dbf83bf" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_5a655251-d0e1-452f-96dd-698e4dbf83bf_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_877506ab-b6b5-4fb2-a083-78e3923452cc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_5a655251-d0e1-452f-96dd-698e4dbf83bf" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_877506ab-b6b5-4fb2-a083-78e3923452cc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansPayableMember_47600d6a-3d58-47c4-a944-71a853bfd454" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoansPayableMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_877506ab-b6b5-4fb2-a083-78e3923452cc" xlink:to="loc_us-gaap_LoansPayableMember_47600d6a-3d58-47c4-a944-71a853bfd454" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateAxis_521974e6-741f-42bd-8509-5251ed9c10e5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VariableRateAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LineOfCreditFacilityTable_5f901001-9b71-4d86-9445-3c60cdbaced2" xlink:to="loc_us-gaap_VariableRateAxis_521974e6-741f-42bd-8509-5251ed9c10e5" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_521974e6-741f-42bd-8509-5251ed9c10e5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VariableRateDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_VariableRateAxis_521974e6-741f-42bd-8509-5251ed9c10e5" xlink:to="loc_us-gaap_VariableRateDomain_521974e6-741f-42bd-8509-5251ed9c10e5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_3be821de-f69a-480b-a6b6-f5e514925e93" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VariableRateDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_VariableRateAxis_521974e6-741f-42bd-8509-5251ed9c10e5" xlink:to="loc_us-gaap_VariableRateDomain_3be821de-f69a-480b-a6b6-f5e514925e93" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateFloorMember_8af19f19-3c2f-4862-9ba2-caedc99d5614" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestRateFloorMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_3be821de-f69a-480b-a6b6-f5e514925e93" xlink:to="loc_us-gaap_InterestRateFloorMember_8af19f19-3c2f-4862-9ba2-caedc99d5614" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cumberlandpharma.com/role/ShareholdersEquityInitialPublicOfferingPreferredStockandCommonStockNarrativeDetails" xlink:type="simple" xlink:href="cpix-20221231.xsd#ShareholdersEquityInitialPublicOfferingPreferredStockandCommonStockNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.cumberlandpharma.com/role/ShareholdersEquityInitialPublicOfferingPreferredStockandCommonStockNarrativeDetails" xlink:type="extended" id="i2433f2921832408caf599edd4d1c1136_ShareholdersEquityInitialPublicOfferingPreferredStockandCommonStockNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_66f017bd-6bd7-494c-b4c2-b0be499f74d1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_InitialPublicOfferingAbstract_2ea9d22a-3fb0-4ca7-8e70-addd5fab37a5" xlink:href="cpix-20221231.xsd#cpix_InitialPublicOfferingAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_66f017bd-6bd7-494c-b4c2-b0be499f74d1" xlink:to="loc_cpix_InitialPublicOfferingAbstract_2ea9d22a-3fb0-4ca7-8e70-addd5fab37a5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockTransactionDate_0d20f993-dcb9-4229-8c06-ae1da85be46f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockTransactionDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cpix_InitialPublicOfferingAbstract_2ea9d22a-3fb0-4ca7-8e70-addd5fab37a5" xlink:to="loc_us-gaap_SaleOfStockTransactionDate_0d20f993-dcb9-4229-8c06-ae1da85be46f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_3c0fdc63-a073-4405-ae7f-a2c4a82120d6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cpix_InitialPublicOfferingAbstract_2ea9d22a-3fb0-4ca7-8e70-addd5fab37a5" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_3c0fdc63-a073-4405-ae7f-a2c4a82120d6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_StockIssuedDuringPeriodPricePerShareNewIssues_94c41572-ba96-4b34-ada1-73be6752efd2" xlink:href="cpix-20221231.xsd#cpix_StockIssuedDuringPeriodPricePerShareNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cpix_InitialPublicOfferingAbstract_2ea9d22a-3fb0-4ca7-8e70-addd5fab37a5" xlink:to="loc_cpix_StockIssuedDuringPeriodPricePerShareNewIssues_94c41572-ba96-4b34-ada1-73be6752efd2" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_StockIssuedDuringPeriodGrossProceedsFromInitialPublicOffering_6700633a-7212-48a7-bb6b-846aa4a38580" xlink:href="cpix-20221231.xsd#cpix_StockIssuedDuringPeriodGrossProceedsFromInitialPublicOffering"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cpix_InitialPublicOfferingAbstract_2ea9d22a-3fb0-4ca7-8e70-addd5fab37a5" xlink:to="loc_cpix_StockIssuedDuringPeriodGrossProceedsFromInitialPublicOffering_6700633a-7212-48a7-bb6b-846aa4a38580" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_StockIssuedDuringPeriodNewSharesUnderwritingDiscounts_1f59aff3-67aa-48cb-a6a0-301c5031d047" xlink:href="cpix-20221231.xsd#cpix_StockIssuedDuringPeriodNewSharesUnderwritingDiscounts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cpix_InitialPublicOfferingAbstract_2ea9d22a-3fb0-4ca7-8e70-addd5fab37a5" xlink:to="loc_cpix_StockIssuedDuringPeriodNewSharesUnderwritingDiscounts_1f59aff3-67aa-48cb-a6a0-301c5031d047" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfStockIssuanceCosts_55aae9dc-5260-49a7-86fd-bd9c1d9dd4bd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsOfStockIssuanceCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cpix_InitialPublicOfferingAbstract_2ea9d22a-3fb0-4ca7-8e70-addd5fab37a5" xlink:to="loc_us-gaap_PaymentsOfStockIssuanceCosts_55aae9dc-5260-49a7-86fd-bd9c1d9dd4bd" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceInitialPublicOffering_67f966c3-1c2c-4212-9471-cc560258d4d8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceInitialPublicOffering"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cpix_InitialPublicOfferingAbstract_2ea9d22a-3fb0-4ca7-8e70-addd5fab37a5" xlink:to="loc_us-gaap_ProceedsFromIssuanceInitialPublicOffering_67f966c3-1c2c-4212-9471-cc560258d4d8" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_PreferredStockAbstract_d1aa818e-78aa-4ba6-bcd8-ab2d28bd580c" xlink:href="cpix-20221231.xsd#cpix_PreferredStockAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_66f017bd-6bd7-494c-b4c2-b0be499f74d1" xlink:to="loc_cpix_PreferredStockAbstract_d1aa818e-78aa-4ba6-bcd8-ab2d28bd580c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_fc09a105-c407-49d8-b888-0c0063b5e760" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cpix_PreferredStockAbstract_d1aa818e-78aa-4ba6-bcd8-ab2d28bd580c" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_fc09a105-c407-49d8-b888-0c0063b5e760" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding_0f8aefbd-bda5-4044-bc4e-131be8313368" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cpix_PreferredStockAbstract_d1aa818e-78aa-4ba6-bcd8-ab2d28bd580c" xlink:to="loc_us-gaap_PreferredStockSharesOutstanding_0f8aefbd-bda5-4044-bc4e-131be8313368" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_CommonStockAbstract_0e4942ea-79b7-4f45-88de-bb94591d45b8" xlink:href="cpix-20221231.xsd#cpix_CommonStockAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_66f017bd-6bd7-494c-b4c2-b0be499f74d1" xlink:to="loc_cpix_CommonStockAbstract_0e4942ea-79b7-4f45-88de-bb94591d45b8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_d4414e7a-1f01-4970-8113-a53ee64d2934" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cpix_CommonStockAbstract_0e4942ea-79b7-4f45-88de-bb94591d45b8" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_d4414e7a-1f01-4970-8113-a53ee64d2934" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_10f2efc7-9bf3-4f97-b9ae-0bbe26d4ca80" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_66f017bd-6bd7-494c-b4c2-b0be499f74d1" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_10f2efc7-9bf3-4f97-b9ae-0bbe26d4ca80" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_aacd2353-2f36-45a9-b041-95a71eadc91b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_10f2efc7-9bf3-4f97-b9ae-0bbe26d4ca80" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_aacd2353-2f36-45a9-b041-95a71eadc91b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_aacd2353-2f36-45a9-b041-95a71eadc91b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_aacd2353-2f36-45a9-b041-95a71eadc91b" xlink:to="loc_us-gaap_EquityComponentDomain_aacd2353-2f36-45a9-b041-95a71eadc91b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_9c749c67-80e5-425f-aba0-d37c773f94c4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_aacd2353-2f36-45a9-b041-95a71eadc91b" xlink:to="loc_us-gaap_EquityComponentDomain_9c749c67-80e5-425f-aba0-d37c773f94c4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_702c7aa9-5db6-4f1f-9f6e-3b464ced3f8c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_9c749c67-80e5-425f-aba0-d37c773f94c4" xlink:to="loc_us-gaap_CommonStockMember_702c7aa9-5db6-4f1f-9f6e-3b464ced3f8c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_b06bdae5-78f5-43d9-9785-fb97af98795c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_10f2efc7-9bf3-4f97-b9ae-0bbe26d4ca80" xlink:to="loc_us-gaap_StatementClassOfStockAxis_b06bdae5-78f5-43d9-9785-fb97af98795c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_b06bdae5-78f5-43d9-9785-fb97af98795c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_b06bdae5-78f5-43d9-9785-fb97af98795c" xlink:to="loc_us-gaap_ClassOfStockDomain_b06bdae5-78f5-43d9-9785-fb97af98795c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_0addf72c-9596-44c8-893f-bd407699c498" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_b06bdae5-78f5-43d9-9785-fb97af98795c" xlink:to="loc_us-gaap_ClassOfStockDomain_0addf72c-9596-44c8-893f-bd407699c498" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_cf133be8-f46d-413e-b437-507d6d969d3e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_0addf72c-9596-44c8-893f-bd407699c498" xlink:to="loc_us-gaap_CommonStockMember_cf133be8-f46d-413e-b437-507d6d969d3e" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cumberlandpharma.com/role/ShareholdersEquityShareRepurchasesCumberlandEmergingTechnologiesandCumberlandFoundationNarrativeDetails" xlink:type="simple" xlink:href="cpix-20221231.xsd#ShareholdersEquityShareRepurchasesCumberlandEmergingTechnologiesandCumberlandFoundationNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.cumberlandpharma.com/role/ShareholdersEquityShareRepurchasesCumberlandEmergingTechnologiesandCumberlandFoundationNarrativeDetails" xlink:type="extended" id="i402c0d33a84848d09ec692bd365ef745_ShareholdersEquityShareRepurchasesCumberlandEmergingTechnologiesandCumberlandFoundationNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityClassOfTreasuryStockLineItems_ce6b3638-d10d-45ad-9d2e-310c0e94b392" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityClassOfTreasuryStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_c90375ff-f2c9-4ec5-bc96-09f5ff88dbee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRepurchaseProgramAuthorizedAmount1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityClassOfTreasuryStockLineItems_ce6b3638-d10d-45ad-9d2e-310c0e94b392" xlink:to="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_c90375ff-f2c9-4ec5-bc96-09f5ff88dbee" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodShares_de0b7352-891b-4874-a6aa-f99981f9ce05" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRepurchasedDuringPeriodShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityClassOfTreasuryStockLineItems_ce6b3638-d10d-45ad-9d2e-310c0e94b392" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodShares_de0b7352-891b-4874-a6aa-f99981f9ce05" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodValue_98205908-1f7b-47fd-b678-925db1734293" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRepurchasedDuringPeriodValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityClassOfTreasuryStockLineItems_ce6b3638-d10d-45ad-9d2e-310c0e94b392" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodValue_98205908-1f7b-47fd-b678-925db1734293" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_43e4f424-6048-4a2c-98fa-c9fb1527b39e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityClassOfTreasuryStockLineItems_ce6b3638-d10d-45ad-9d2e-310c0e94b392" xlink:to="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_43e4f424-6048-4a2c-98fa-c9fb1527b39e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfTreasuryStockTable_5a8659c5-ef97-4edf-9fc7-6598de24611c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfTreasuryStockTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EquityClassOfTreasuryStockLineItems_ce6b3638-d10d-45ad-9d2e-310c0e94b392" xlink:to="loc_us-gaap_ClassOfTreasuryStockTable_5a8659c5-ef97-4edf-9fc7-6598de24611c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareRepurchaseProgramAxis_420399f8-e623-43b5-9857-39328671d04b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareRepurchaseProgramAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfTreasuryStockTable_5a8659c5-ef97-4edf-9fc7-6598de24611c" xlink:to="loc_us-gaap_ShareRepurchaseProgramAxis_420399f8-e623-43b5-9857-39328671d04b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareRepurchaseProgramDomain_420399f8-e623-43b5-9857-39328671d04b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareRepurchaseProgramDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis_420399f8-e623-43b5-9857-39328671d04b" xlink:to="loc_us-gaap_ShareRepurchaseProgramDomain_420399f8-e623-43b5-9857-39328671d04b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareRepurchaseProgramDomain_8e4a3935-7189-4419-95ba-87e95e24d84e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareRepurchaseProgramDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis_420399f8-e623-43b5-9857-39328671d04b" xlink:to="loc_us-gaap_ShareRepurchaseProgramDomain_8e4a3935-7189-4419-95ba-87e95e24d84e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_ShareRepurchaseProgramAuthorizedIn2010Member_74dcd749-ab5f-4529-b27c-f9fafe63423c" xlink:href="cpix-20221231.xsd#cpix_ShareRepurchaseProgramAuthorizedIn2010Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareRepurchaseProgramDomain_8e4a3935-7189-4419-95ba-87e95e24d84e" xlink:to="loc_cpix_ShareRepurchaseProgramAuthorizedIn2010Member_74dcd749-ab5f-4529-b27c-f9fafe63423c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_SharesRepurchaseActivityTypeAxis_02d05766-5f38-4710-be6f-023e36207ab3" xlink:href="cpix-20221231.xsd#cpix_SharesRepurchaseActivityTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfTreasuryStockTable_5a8659c5-ef97-4edf-9fc7-6598de24611c" xlink:to="loc_cpix_SharesRepurchaseActivityTypeAxis_02d05766-5f38-4710-be6f-023e36207ab3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_SharesRepurchaseActivityTypeDomain_02d05766-5f38-4710-be6f-023e36207ab3_default" xlink:href="cpix-20221231.xsd#cpix_SharesRepurchaseActivityTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_cpix_SharesRepurchaseActivityTypeAxis_02d05766-5f38-4710-be6f-023e36207ab3" xlink:to="loc_cpix_SharesRepurchaseActivityTypeDomain_02d05766-5f38-4710-be6f-023e36207ab3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_SharesRepurchaseActivityTypeDomain_544be10f-7f7f-4ff5-b64b-4479961e1acd" xlink:href="cpix-20221231.xsd#cpix_SharesRepurchaseActivityTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_cpix_SharesRepurchaseActivityTypeAxis_02d05766-5f38-4710-be6f-023e36207ab3" xlink:to="loc_cpix_SharesRepurchaseActivityTypeDomain_544be10f-7f7f-4ff5-b64b-4479961e1acd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_SharesRepurchaseAllExceptSettlementOfTaxLiabilitiesRelatedToExerciseOfStockOptionsMember_c64eb281-666f-4f7e-9dd1-00bdec867270" xlink:href="cpix-20221231.xsd#cpix_SharesRepurchaseAllExceptSettlementOfTaxLiabilitiesRelatedToExerciseOfStockOptionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cpix_SharesRepurchaseActivityTypeDomain_544be10f-7f7f-4ff5-b64b-4479961e1acd" xlink:to="loc_cpix_SharesRepurchaseAllExceptSettlementOfTaxLiabilitiesRelatedToExerciseOfStockOptionsMember_c64eb281-666f-4f7e-9dd1-00bdec867270" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cumberlandpharma.com/role/IncomeTaxesScheduleofNetOperatingLossCarryforwardsDetails" xlink:type="simple" xlink:href="cpix-20221231.xsd#IncomeTaxesScheduleofNetOperatingLossCarryforwardsDetails"/>
  <link:definitionLink xlink:role="http://www.cumberlandpharma.com/role/IncomeTaxesScheduleofNetOperatingLossCarryforwardsDetails" xlink:type="extended" id="ic1e117d649a74fc9af7c9638eb67f8e7_IncomeTaxesScheduleofNetOperatingLossCarryforwardsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwardsLineItems_bfb74d5c-b24f-424b-8359-7e09c322868f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLossCarryforwardsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwards_d4d9bed1-8c95-45c5-b3e6-e121564d0063" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLossCarryforwards"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_bfb74d5c-b24f-424b-8359-7e09c322868f" xlink:to="loc_us-gaap_OperatingLossCarryforwards_d4d9bed1-8c95-45c5-b3e6-e121564d0063" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwardsTable_c880a068-f288-4f06-b786-091bd6975002" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLossCarryforwardsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_bfb74d5c-b24f-424b-8359-7e09c322868f" xlink:to="loc_us-gaap_OperatingLossCarryforwardsTable_c880a068-f288-4f06-b786-091bd6975002" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_ExpirationTimePeriodAxis_870b6cfe-a8a3-4b64-9e7a-b7f6ad028895" xlink:href="cpix-20221231.xsd#cpix_ExpirationTimePeriodAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_c880a068-f288-4f06-b786-091bd6975002" xlink:to="loc_cpix_ExpirationTimePeriodAxis_870b6cfe-a8a3-4b64-9e7a-b7f6ad028895" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_ExpirationTimePeriodDomain_870b6cfe-a8a3-4b64-9e7a-b7f6ad028895_default" xlink:href="cpix-20221231.xsd#cpix_ExpirationTimePeriodDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_cpix_ExpirationTimePeriodAxis_870b6cfe-a8a3-4b64-9e7a-b7f6ad028895" xlink:to="loc_cpix_ExpirationTimePeriodDomain_870b6cfe-a8a3-4b64-9e7a-b7f6ad028895_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_ExpirationTimePeriodDomain_0a8990c2-8436-488f-99af-e7627f577a4f" xlink:href="cpix-20221231.xsd#cpix_ExpirationTimePeriodDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_cpix_ExpirationTimePeriodAxis_870b6cfe-a8a3-4b64-9e7a-b7f6ad028895" xlink:to="loc_cpix_ExpirationTimePeriodDomain_0a8990c2-8436-488f-99af-e7627f577a4f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_ExpirationTermOneMember_db8091ac-bff0-418a-b866-92771cfef682" xlink:href="cpix-20221231.xsd#cpix_ExpirationTermOneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cpix_ExpirationTimePeriodDomain_0a8990c2-8436-488f-99af-e7627f577a4f" xlink:to="loc_cpix_ExpirationTermOneMember_db8091ac-bff0-418a-b866-92771cfef682" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_ExpirationTermTwoMember_7ad2900c-4114-4521-adb0-239c94345be3" xlink:href="cpix-20221231.xsd#cpix_ExpirationTermTwoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cpix_ExpirationTimePeriodDomain_0a8990c2-8436-488f-99af-e7627f577a4f" xlink:to="loc_cpix_ExpirationTermTwoMember_7ad2900c-4114-4521-adb0-239c94345be3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_IndefiniteMember_73b9d5d9-40bd-4e48-9b4c-52c3ff25193d" xlink:href="cpix-20221231.xsd#cpix_IndefiniteMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cpix_ExpirationTimePeriodDomain_0a8990c2-8436-488f-99af-e7627f577a4f" xlink:to="loc_cpix_IndefiniteMember_73b9d5d9-40bd-4e48-9b4c-52c3ff25193d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis_88bc6972-204b-454c-885b-38068268e5fd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxAuthorityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_c880a068-f288-4f06-b786-091bd6975002" xlink:to="loc_us-gaap_IncomeTaxAuthorityAxis_88bc6972-204b-454c-885b-38068268e5fd" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_88bc6972-204b-454c-885b-38068268e5fd_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_88bc6972-204b-454c-885b-38068268e5fd" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_88bc6972-204b-454c-885b-38068268e5fd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_5cc9fa7e-07de-4e64-b46e-0798f20c5651" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_88bc6972-204b-454c-885b-38068268e5fd" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_5cc9fa7e-07de-4e64-b46e-0798f20c5651" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InternalRevenueServiceIRSMember_92e5a469-0d6a-42c8-ad43-62dfae309f5a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InternalRevenueServiceIRSMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_5cc9fa7e-07de-4e64-b46e-0798f20c5651" xlink:to="loc_us-gaap_InternalRevenueServiceIRSMember_92e5a469-0d6a-42c8-ad43-62dfae309f5a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StateAndLocalJurisdictionMember_e9e4c16a-be7f-4f5d-a630-f51068ff71b1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StateAndLocalJurisdictionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_5cc9fa7e-07de-4e64-b46e-0798f20c5651" xlink:to="loc_us-gaap_StateAndLocalJurisdictionMember_e9e4c16a-be7f-4f5d-a630-f51068ff71b1" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cumberlandpharma.com/role/IncomeTaxesScheduleoftaxcreditcarryforwardsDetails" xlink:type="simple" xlink:href="cpix-20221231.xsd#IncomeTaxesScheduleoftaxcreditcarryforwardsDetails"/>
  <link:definitionLink xlink:role="http://www.cumberlandpharma.com/role/IncomeTaxesScheduleoftaxcreditcarryforwardsDetails" xlink:type="extended" id="i3f8b123067d74ecd80e3715c564a2f13_IncomeTaxesScheduleoftaxcreditcarryforwardsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardLineItems_79a49b4c-3bba-4361-9c46-579ee68f17b4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TaxCreditCarryforwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardAmount_1ec23eb1-0448-43ec-bdf8-b431de249d64" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TaxCreditCarryforwardAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TaxCreditCarryforwardLineItems_79a49b4c-3bba-4361-9c46-579ee68f17b4" xlink:to="loc_us-gaap_TaxCreditCarryforwardAmount_1ec23eb1-0448-43ec-bdf8-b431de249d64" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardTable_196a5ae9-4c1f-4bc9-9252-4697496b7590" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TaxCreditCarryforwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_TaxCreditCarryforwardLineItems_79a49b4c-3bba-4361-9c46-579ee68f17b4" xlink:to="loc_us-gaap_TaxCreditCarryforwardTable_196a5ae9-4c1f-4bc9-9252-4697496b7590" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_ExpirationTimePeriodAxis_bc405a39-9f01-4592-8aaf-cab007d1aaeb" xlink:href="cpix-20221231.xsd#cpix_ExpirationTimePeriodAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_TaxCreditCarryforwardTable_196a5ae9-4c1f-4bc9-9252-4697496b7590" xlink:to="loc_cpix_ExpirationTimePeriodAxis_bc405a39-9f01-4592-8aaf-cab007d1aaeb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_ExpirationTimePeriodDomain_bc405a39-9f01-4592-8aaf-cab007d1aaeb_default" xlink:href="cpix-20221231.xsd#cpix_ExpirationTimePeriodDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_cpix_ExpirationTimePeriodAxis_bc405a39-9f01-4592-8aaf-cab007d1aaeb" xlink:to="loc_cpix_ExpirationTimePeriodDomain_bc405a39-9f01-4592-8aaf-cab007d1aaeb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_ExpirationTimePeriodDomain_7fa8d34a-e3f6-4951-97bb-f31ba06fcd97" xlink:href="cpix-20221231.xsd#cpix_ExpirationTimePeriodDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_cpix_ExpirationTimePeriodAxis_bc405a39-9f01-4592-8aaf-cab007d1aaeb" xlink:to="loc_cpix_ExpirationTimePeriodDomain_7fa8d34a-e3f6-4951-97bb-f31ba06fcd97" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_ExpirationTermOneMember_aac02f3b-cadd-43ab-a891-32fee840d5e5" xlink:href="cpix-20221231.xsd#cpix_ExpirationTermOneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cpix_ExpirationTimePeriodDomain_7fa8d34a-e3f6-4951-97bb-f31ba06fcd97" xlink:to="loc_cpix_ExpirationTermOneMember_aac02f3b-cadd-43ab-a891-32fee840d5e5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_ExpirationTermTwoMember_4277d55b-28b7-4c20-ab1f-015132b88e1f" xlink:href="cpix-20221231.xsd#cpix_ExpirationTermTwoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cpix_ExpirationTimePeriodDomain_7fa8d34a-e3f6-4951-97bb-f31ba06fcd97" xlink:to="loc_cpix_ExpirationTermTwoMember_4277d55b-28b7-4c20-ab1f-015132b88e1f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis_cd72e726-624f-4bc5-96b3-c85071a67138" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxAuthorityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_TaxCreditCarryforwardTable_196a5ae9-4c1f-4bc9-9252-4697496b7590" xlink:to="loc_us-gaap_IncomeTaxAuthorityAxis_cd72e726-624f-4bc5-96b3-c85071a67138" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_cd72e726-624f-4bc5-96b3-c85071a67138_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_cd72e726-624f-4bc5-96b3-c85071a67138" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_cd72e726-624f-4bc5-96b3-c85071a67138_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_8c2291ad-9f49-4f4b-b02e-9d7a6782f3be" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_cd72e726-624f-4bc5-96b3-c85071a67138" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_8c2291ad-9f49-4f4b-b02e-9d7a6782f3be" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_FederalAndStateMember_50ab0f65-ca16-4658-b705-86f75651c935" xlink:href="cpix-20221231.xsd#cpix_FederalAndStateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_8c2291ad-9f49-4f4b-b02e-9d7a6782f3be" xlink:to="loc_cpix_FederalAndStateMember_50ab0f65-ca16-4658-b705-86f75651c935" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cumberlandpharma.com/role/StockBasedCompensationPlansNarrativeDetails" xlink:type="simple" xlink:href="cpix-20221231.xsd#StockBasedCompensationPlansNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.cumberlandpharma.com/role/StockBasedCompensationPlansNarrativeDetails" xlink:type="extended" id="i83ec52407f51422588f484a569d5c635_StockBasedCompensationPlansNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3dc6ac90-edd8-4b16-bef6-9ea730499fb9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfPlansAvailableForFutureGrants_eaf7f9b4-ccc5-4eab-a0d9-6a9b4159c7e8" xlink:href="cpix-20221231.xsd#cpix_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfPlansAvailableForFutureGrants"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3dc6ac90-edd8-4b16-bef6-9ea730499fb9" xlink:to="loc_cpix_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfPlansAvailableForFutureGrants_eaf7f9b4-ccc5-4eab-a0d9-6a9b4159c7e8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_de026bb2-6708-481b-adb9-9d36b6cc8ed9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3dc6ac90-edd8-4b16-bef6-9ea730499fb9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_de026bb2-6708-481b-adb9-9d36b6cc8ed9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisePriceAsPercentOfWeightedAverageGrantDateFairValue_5bbd5222-f7d3-493b-945f-b18362fa016f" xlink:href="cpix-20221231.xsd#cpix_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisePriceAsPercentOfWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3dc6ac90-edd8-4b16-bef6-9ea730499fb9" xlink:to="loc_cpix_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisePriceAsPercentOfWeightedAverageGrantDateFairValue_5bbd5222-f7d3-493b-945f-b18362fa016f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_6ba0bfd6-cabc-4792-b2d1-a1b8d595a418" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3dc6ac90-edd8-4b16-bef6-9ea730499fb9" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_6ba0bfd6-cabc-4792-b2d1-a1b8d595a418" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_ShareBasedCompensationArrangementByShareBasedPaymentAwardShareholderPercent_c8fb054c-2168-4a27-a616-6477f99a2f00" xlink:href="cpix-20221231.xsd#cpix_ShareBasedCompensationArrangementByShareBasedPaymentAwardShareholderPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3dc6ac90-edd8-4b16-bef6-9ea730499fb9" xlink:to="loc_cpix_ShareBasedCompensationArrangementByShareBasedPaymentAwardShareholderPercent_c8fb054c-2168-4a27-a616-6477f99a2f00" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_67e9b780-dfa6-41c4-bb41-f407fce10c2e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3dc6ac90-edd8-4b16-bef6-9ea730499fb9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_67e9b780-dfa6-41c4-bb41-f407fce10c2e" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_4bc60c07-15c2-4fe3-bb55-832eb6fbaa80" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3dc6ac90-edd8-4b16-bef6-9ea730499fb9" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_4bc60c07-15c2-4fe3-bb55-832eb6fbaa80" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_665a4388-f952-4ec3-af27-19cd76b2582c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3dc6ac90-edd8-4b16-bef6-9ea730499fb9" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_665a4388-f952-4ec3-af27-19cd76b2582c" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_dab7f8d7-7ecb-4395-8038-474b498cf518" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3dc6ac90-edd8-4b16-bef6-9ea730499fb9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_dab7f8d7-7ecb-4395-8038-474b498cf518" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_eb75f4fb-60eb-4a1b-b6bb-2cda9fc3b45f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3dc6ac90-edd8-4b16-bef6-9ea730499fb9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_eb75f4fb-60eb-4a1b-b6bb-2cda9fc3b45f" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_6345f537-5977-40ee-b569-08707636448b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3dc6ac90-edd8-4b16-bef6-9ea730499fb9" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_6345f537-5977-40ee-b569-08707636448b" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_bdcaf1e6-3148-44e1-a796-915681f1957c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3dc6ac90-edd8-4b16-bef6-9ea730499fb9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_bdcaf1e6-3148-44e1-a796-915681f1957c" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsWeightedAverageVolatilityRate_434d113b-c126-410b-aca8-5897e71395b2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsWeightedAverageVolatilityRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3dc6ac90-edd8-4b16-bef6-9ea730499fb9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsWeightedAverageVolatilityRate_434d113b-c126-410b-aca8-5897e71395b2" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_2f1c7dfb-62bb-432a-911a-90cd46d3376d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3dc6ac90-edd8-4b16-bef6-9ea730499fb9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_2f1c7dfb-62bb-432a-911a-90cd46d3376d" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendPayments_2c005a76-0264-4baf-9b14-bc1f5811b261" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendPayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3dc6ac90-edd8-4b16-bef6-9ea730499fb9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendPayments_2c005a76-0264-4baf-9b14-bc1f5811b261" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_6832f77b-3152-4103-b282-95b44c74f65f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3dc6ac90-edd8-4b16-bef6-9ea730499fb9" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_6832f77b-3152-4103-b282-95b44c74f65f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_182380e9-dee4-4d01-a7cc-b77a74cf42db" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_6832f77b-3152-4103-b282-95b44c74f65f" xlink:to="loc_us-gaap_AwardTypeAxis_182380e9-dee4-4d01-a7cc-b77a74cf42db" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_182380e9-dee4-4d01-a7cc-b77a74cf42db_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_182380e9-dee4-4d01-a7cc-b77a74cf42db" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_182380e9-dee4-4d01-a7cc-b77a74cf42db_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_1c2eb3a6-dd6a-4d2e-ba72-89b2c59f306f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_182380e9-dee4-4d01-a7cc-b77a74cf42db" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_1c2eb3a6-dd6a-4d2e-ba72-89b2c59f306f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_b4f25964-14fd-4c8b-a646-010e4b97f163" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_1c2eb3a6-dd6a-4d2e-ba72-89b2c59f306f" xlink:to="loc_us-gaap_EmployeeStockOptionMember_b4f25964-14fd-4c8b-a646-010e4b97f163" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockMember_b3207844-6178-450d-8c5d-3104b5138166" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_1c2eb3a6-dd6a-4d2e-ba72-89b2c59f306f" xlink:to="loc_us-gaap_RestrictedStockMember_b3207844-6178-450d-8c5d-3104b5138166" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_d635a610-0c59-4635-a4af-122a5d28e398" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_6832f77b-3152-4103-b282-95b44c74f65f" xlink:to="loc_us-gaap_PlanNameAxis_d635a610-0c59-4635-a4af-122a5d28e398" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_d635a610-0c59-4635-a4af-122a5d28e398_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_d635a610-0c59-4635-a4af-122a5d28e398" xlink:to="loc_us-gaap_PlanNameDomain_d635a610-0c59-4635-a4af-122a5d28e398_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_1b5930db-e716-406d-9ea9-e6215c352532" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_d635a610-0c59-4635-a4af-122a5d28e398" xlink:to="loc_us-gaap_PlanNameDomain_1b5930db-e716-406d-9ea9-e6215c352532" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_LongTermIncentiveCompensationPlan2007Member_5ab42ab7-b072-405b-9670-3d68eda0c5e8" xlink:href="cpix-20221231.xsd#cpix_LongTermIncentiveCompensationPlan2007Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_1b5930db-e716-406d-9ea9-e6215c352532" xlink:to="loc_cpix_LongTermIncentiveCompensationPlan2007Member_5ab42ab7-b072-405b-9670-3d68eda0c5e8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_DirectorsIncentivePlan2007Member_2cb04433-2d8c-4877-807f-5c95513ccedf" xlink:href="cpix-20221231.xsd#cpix_DirectorsIncentivePlan2007Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_1b5930db-e716-406d-9ea9-e6215c352532" xlink:to="loc_cpix_DirectorsIncentivePlan2007Member_2cb04433-2d8c-4877-807f-5c95513ccedf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualAxis_e4ba74cd-96d7-4c57-a852-2633bda6efdc" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_TitleOfIndividualAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_6832f77b-3152-4103-b282-95b44c74f65f" xlink:to="loc_srt_TitleOfIndividualAxis_e4ba74cd-96d7-4c57-a852-2633bda6efdc" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_e4ba74cd-96d7-4c57-a852-2633bda6efdc_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_TitleOfIndividualWithRelationshipToEntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_TitleOfIndividualAxis_e4ba74cd-96d7-4c57-a852-2633bda6efdc" xlink:to="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_e4ba74cd-96d7-4c57-a852-2633bda6efdc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_0589db5d-5d1c-437e-b52f-f8d0e8d0be3d" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_TitleOfIndividualWithRelationshipToEntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_TitleOfIndividualAxis_e4ba74cd-96d7-4c57-a852-2633bda6efdc" xlink:to="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_0589db5d-5d1c-437e-b52f-f8d0e8d0be3d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_EmployeeMember_f4e2b9c7-ddc1-4a9a-9e91-56e9e0d64ef8" xlink:href="cpix-20221231.xsd#cpix_EmployeeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_0589db5d-5d1c-437e-b52f-f8d0e8d0be3d" xlink:to="loc_cpix_EmployeeMember_f4e2b9c7-ddc1-4a9a-9e91-56e9e0d64ef8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrincipalOwnerMember_f7b9a146-6c78-4197-95d5-4c7ee1551539" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PrincipalOwnerMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_0589db5d-5d1c-437e-b52f-f8d0e8d0be3d" xlink:to="loc_us-gaap_PrincipalOwnerMember_f7b9a146-6c78-4197-95d5-4c7ee1551539" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_NonprincipalOwnerMember_ed5a97c0-b3e9-4412-b502-bbf8a21a0e88" xlink:href="cpix-20221231.xsd#cpix_NonprincipalOwnerMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_0589db5d-5d1c-437e-b52f-f8d0e8d0be3d" xlink:to="loc_cpix_NonprincipalOwnerMember_ed5a97c0-b3e9-4412-b502-bbf8a21a0e88" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_DirectorMember_f4ddfe2e-4d34-4dce-8515-d7689b9c70f8" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_DirectorMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_0589db5d-5d1c-437e-b52f-f8d0e8d0be3d" xlink:to="loc_srt_DirectorMember_f4ddfe2e-4d34-4dce-8515-d7689b9c70f8" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_b789f136-b767-42ce-8f2f-15c5ff413ee6" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_6832f77b-3152-4103-b282-95b44c74f65f" xlink:to="loc_srt_RangeAxis_b789f136-b767-42ce-8f2f-15c5ff413ee6" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_b789f136-b767-42ce-8f2f-15c5ff413ee6_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_b789f136-b767-42ce-8f2f-15c5ff413ee6" xlink:to="loc_srt_RangeMember_b789f136-b767-42ce-8f2f-15c5ff413ee6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_11d37871-6d06-4f79-b2fb-ee13c8c995ee" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_b789f136-b767-42ce-8f2f-15c5ff413ee6" xlink:to="loc_srt_RangeMember_11d37871-6d06-4f79-b2fb-ee13c8c995ee" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_981348f7-59ae-4003-9e29-8195243460c2" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_11d37871-6d06-4f79-b2fb-ee13c8c995ee" xlink:to="loc_srt_MinimumMember_981348f7-59ae-4003-9e29-8195243460c2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_3865b9c6-bb1e-47a2-9b35-363d52508d8a" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_11d37871-6d06-4f79-b2fb-ee13c8c995ee" xlink:to="loc_srt_MaximumMember_3865b9c6-bb1e-47a2-9b35-363d52508d8a" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cumberlandpharma.com/role/StockBasedCompensationPlansScheduleofShareBasedCompensationExpenseDetails" xlink:type="simple" xlink:href="cpix-20221231.xsd#StockBasedCompensationPlansScheduleofShareBasedCompensationExpenseDetails"/>
  <link:definitionLink xlink:role="http://www.cumberlandpharma.com/role/StockBasedCompensationPlansScheduleofShareBasedCompensationExpenseDetails" xlink:type="extended" id="ie67864ddba4b4430b2868393e8e5d479_StockBasedCompensationPlansScheduleofShareBasedCompensationExpenseDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_07d33f5c-e6e9-476f-bdec-c46e789137c9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_68bc8ce0-c9bf-47c9-aa60-cbe3dcde90a1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_07d33f5c-e6e9-476f-bdec-c46e789137c9" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_68bc8ce0-c9bf-47c9-aa60-cbe3dcde90a1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_87c1d90d-46b6-4ab8-b97d-12295cbe75be" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_07d33f5c-e6e9-476f-bdec-c46e789137c9" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_87c1d90d-46b6-4ab8-b97d-12295cbe75be" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualAxis_2f89b6f3-348a-4b66-991a-b731f8f61f69" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_TitleOfIndividualAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_87c1d90d-46b6-4ab8-b97d-12295cbe75be" xlink:to="loc_srt_TitleOfIndividualAxis_2f89b6f3-348a-4b66-991a-b731f8f61f69" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_2f89b6f3-348a-4b66-991a-b731f8f61f69_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_TitleOfIndividualWithRelationshipToEntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_TitleOfIndividualAxis_2f89b6f3-348a-4b66-991a-b731f8f61f69" xlink:to="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_2f89b6f3-348a-4b66-991a-b731f8f61f69_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_aefdb281-1ee5-434c-beea-fbcc5d9967b7" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_TitleOfIndividualWithRelationshipToEntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_TitleOfIndividualAxis_2f89b6f3-348a-4b66-991a-b731f8f61f69" xlink:to="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_aefdb281-1ee5-434c-beea-fbcc5d9967b7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_EmployeeMember_aa7e897c-01e2-46c9-8613-dfbc15b66203" xlink:href="cpix-20221231.xsd#cpix_EmployeeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_aefdb281-1ee5-434c-beea-fbcc5d9967b7" xlink:to="loc_cpix_EmployeeMember_aa7e897c-01e2-46c9-8613-dfbc15b66203" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_NonemployeeMember_45a1115a-8297-4639-80ee-afc6c9c65d43" xlink:href="cpix-20221231.xsd#cpix_NonemployeeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_aefdb281-1ee5-434c-beea-fbcc5d9967b7" xlink:to="loc_cpix_NonemployeeMember_45a1115a-8297-4639-80ee-afc6c9c65d43" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_EmployeeNonemployeeandFoundationContributionMember_60a6daa2-5c7e-45dd-b26a-ba055a17172e" xlink:href="cpix-20221231.xsd#cpix_EmployeeNonemployeeandFoundationContributionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_aefdb281-1ee5-434c-beea-fbcc5d9967b7" xlink:to="loc_cpix_EmployeeNonemployeeandFoundationContributionMember_60a6daa2-5c7e-45dd-b26a-ba055a17172e" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cumberlandpharma.com/role/StockBasedCompensationPlansScheduleofRestrictedIncentiveStockActivityDetails" xlink:type="simple" xlink:href="cpix-20221231.xsd#StockBasedCompensationPlansScheduleofRestrictedIncentiveStockActivityDetails"/>
  <link:definitionLink xlink:role="http://www.cumberlandpharma.com/role/StockBasedCompensationPlansScheduleofRestrictedIncentiveStockActivityDetails" xlink:type="extended" id="icd82379be2f7479697940dddc8207243_StockBasedCompensationPlansScheduleofRestrictedIncentiveStockActivityDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c48a668c-5380-4166-ba3a-453ab677e38d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_a92912e7-86e9-41cd-90fb-58c404acb080" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c48a668c-5380-4166-ba3a-453ab677e38d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_a92912e7-86e9-41cd-90fb-58c404acb080" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_b519cf84-1959-443a-b97b-765328727a13" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_a92912e7-86e9-41cd-90fb-58c404acb080" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_b519cf84-1959-443a-b97b-765328727a13" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_8d0cbfbd-c39a-48df-9447-a047cbc8e166" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_a92912e7-86e9-41cd-90fb-58c404acb080" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_8d0cbfbd-c39a-48df-9447-a047cbc8e166" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedNumberOfShares_1d7586c6-495f-43be-9c2e-6325b8b1ca6c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedNumberOfShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_a92912e7-86e9-41cd-90fb-58c404acb080" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedNumberOfShares_1d7586c6-495f-43be-9c2e-6325b8b1ca6c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_54560565-80be-4c3c-ac0f-061066dce3ef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_a92912e7-86e9-41cd-90fb-58c404acb080" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_54560565-80be-4c3c-ac0f-061066dce3ef" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_b4d31500-a1e4-473f-9034-a09d359ca485" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_7772ff51-29d3-420a-8bbc-06e30294f95e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c48a668c-5380-4166-ba3a-453ab677e38d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_7772ff51-29d3-420a-8bbc-06e30294f95e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_d34b9755-ee19-44fc-ac8d-fab36f67b89f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_7772ff51-29d3-420a-8bbc-06e30294f95e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_d34b9755-ee19-44fc-ac8d-fab36f67b89f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_c3c086af-3b94-409f-b2dd-f0bcd931819d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_7772ff51-29d3-420a-8bbc-06e30294f95e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_c3c086af-3b94-409f-b2dd-f0bcd931819d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedWeightedAverageGrantDateFairValue_b1321d9c-9c5a-4f8c-8f7a-ddf19c44b400" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_7772ff51-29d3-420a-8bbc-06e30294f95e" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedWeightedAverageGrantDateFairValue_b1321d9c-9c5a-4f8c-8f7a-ddf19c44b400" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_be97d0ac-b560-4fa9-854a-476be0f9dbc6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_7772ff51-29d3-420a-8bbc-06e30294f95e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_be97d0ac-b560-4fa9-854a-476be0f9dbc6" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_ad017af4-c592-43c8-8804-2435a92ffccb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_206ee39d-dac1-41c5-9a8b-bbfa395b14b9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c48a668c-5380-4166-ba3a-453ab677e38d" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_206ee39d-dac1-41c5-9a8b-bbfa395b14b9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_29c21d72-9c56-4763-a9c0-65f23b8051f8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c48a668c-5380-4166-ba3a-453ab677e38d" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_29c21d72-9c56-4763-a9c0-65f23b8051f8" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_fe374aea-0dc1-49e7-90bb-fb8ebe068131" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_29c21d72-9c56-4763-a9c0-65f23b8051f8" xlink:to="loc_us-gaap_AwardTypeAxis_fe374aea-0dc1-49e7-90bb-fb8ebe068131" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_fe374aea-0dc1-49e7-90bb-fb8ebe068131_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_fe374aea-0dc1-49e7-90bb-fb8ebe068131" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_fe374aea-0dc1-49e7-90bb-fb8ebe068131_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_ebd64470-4be3-49d4-9e61-4f3b26f179e2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_fe374aea-0dc1-49e7-90bb-fb8ebe068131" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_ebd64470-4be3-49d4-9e61-4f3b26f179e2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_RestrictedIncentiveStockOptionsMember_74d06984-fa93-4992-b007-a5de01b8f645" xlink:href="cpix-20221231.xsd#cpix_RestrictedIncentiveStockOptionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_ebd64470-4be3-49d4-9e61-4f3b26f179e2" xlink:to="loc_cpix_RestrictedIncentiveStockOptionsMember_74d06984-fa93-4992-b007-a5de01b8f645" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cumberlandpharma.com/role/StockBasedCompensationPlansScheduleofRestrictedStockActivityDetails" xlink:type="simple" xlink:href="cpix-20221231.xsd#StockBasedCompensationPlansScheduleofRestrictedStockActivityDetails"/>
  <link:definitionLink xlink:role="http://www.cumberlandpharma.com/role/StockBasedCompensationPlansScheduleofRestrictedStockActivityDetails" xlink:type="extended" id="i91a4fccd103347ef82cd609ecaa02083_StockBasedCompensationPlansScheduleofRestrictedStockActivityDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_a2d2108c-ab87-4676-9eb8-e34629a27c7e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_e7ce31ec-e300-4de9-a6e0-38e0516040c3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_a2d2108c-ab87-4676-9eb8-e34629a27c7e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_e7ce31ec-e300-4de9-a6e0-38e0516040c3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_ed08e0e2-0a4e-44d9-ae2b-1b091ab083d3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_e7ce31ec-e300-4de9-a6e0-38e0516040c3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_ed08e0e2-0a4e-44d9-ae2b-1b091ab083d3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_58aa0779-6786-4dce-b86a-db2c536696e4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_e7ce31ec-e300-4de9-a6e0-38e0516040c3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_58aa0779-6786-4dce-b86a-db2c536696e4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_3884f770-2e1c-43fb-b2be-efe291a911c6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_e7ce31ec-e300-4de9-a6e0-38e0516040c3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_3884f770-2e1c-43fb-b2be-efe291a911c6" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_04fce73b-063e-43e9-8bfa-5980e7b92a5f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_e7ce31ec-e300-4de9-a6e0-38e0516040c3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_04fce73b-063e-43e9-8bfa-5980e7b92a5f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_c63d9af0-fa50-4702-984f-20f2809f2e9f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_fd69b42f-9b7f-4988-8c82-e0f2df65d71c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_a2d2108c-ab87-4676-9eb8-e34629a27c7e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_fd69b42f-9b7f-4988-8c82-e0f2df65d71c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_36cdc9ca-ccd6-4ce0-b951-e1781192f374" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_fd69b42f-9b7f-4988-8c82-e0f2df65d71c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_36cdc9ca-ccd6-4ce0-b951-e1781192f374" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_11ac44a8-7445-4592-997e-ea01b108ef5f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_fd69b42f-9b7f-4988-8c82-e0f2df65d71c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_11ac44a8-7445-4592-997e-ea01b108ef5f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_4241b1d6-2224-4c98-be4c-e421a96209c4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_fd69b42f-9b7f-4988-8c82-e0f2df65d71c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_4241b1d6-2224-4c98-be4c-e421a96209c4" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_7dafecfd-81eb-43a0-9cfa-50116c66131c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_fd69b42f-9b7f-4988-8c82-e0f2df65d71c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_7dafecfd-81eb-43a0-9cfa-50116c66131c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_e69e3d80-a95e-4438-9bf5-10bbef3ce373" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_84d95319-8558-430d-83e4-f6ea9abe22f4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_a2d2108c-ab87-4676-9eb8-e34629a27c7e" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_84d95319-8558-430d-83e4-f6ea9abe22f4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_2d29d21d-7866-43dc-8cbf-6c8666276fd9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_84d95319-8558-430d-83e4-f6ea9abe22f4" xlink:to="loc_us-gaap_AwardTypeAxis_2d29d21d-7866-43dc-8cbf-6c8666276fd9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_2d29d21d-7866-43dc-8cbf-6c8666276fd9_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_2d29d21d-7866-43dc-8cbf-6c8666276fd9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_2d29d21d-7866-43dc-8cbf-6c8666276fd9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_e69955c1-542d-471a-8734-e1c39d8d1582" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_2d29d21d-7866-43dc-8cbf-6c8666276fd9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_e69955c1-542d-471a-8734-e1c39d8d1582" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockMember_214fae82-c34a-4e6f-b629-cfbadc99feb5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_e69955c1-542d-471a-8734-e1c39d8d1582" xlink:to="loc_us-gaap_RestrictedStockMember_214fae82-c34a-4e6f-b629-cfbadc99feb5" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cumberlandpharma.com/role/LeasesNarrativeDetails" xlink:type="simple" xlink:href="cpix-20221231.xsd#LeasesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.cumberlandpharma.com/role/LeasesNarrativeDetails" xlink:type="extended" id="i4049f7f2c52e4895916f6652ce104569_LeasesNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionLineItems_914dba70-c6c6-438c-838b-7824ac252578" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeLeaseDescriptionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_LesseeOperatingLeaseLeasedArea_51e820bc-4fe5-40e3-aeb5-9169c642e3aa" xlink:href="cpix-20221231.xsd#cpix_LesseeOperatingLeaseLeasedArea"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_914dba70-c6c6-438c-838b-7824ac252578" xlink:to="loc_cpix_LesseeOperatingLeaseLeasedArea_51e820bc-4fe5-40e3-aeb5-9169c642e3aa" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseTermOfContract_f06353a2-e3b5-4fd6-9132-4fd8a1a44cdc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseTermOfContract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_914dba70-c6c6-438c-838b-7824ac252578" xlink:to="loc_us-gaap_LesseeOperatingLeaseTermOfContract_f06353a2-e3b5-4fd6-9132-4fd8a1a44cdc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_LesseeOperatingLeaseNumberOfRenewalTerms_c213b133-359f-44aa-ac72-4fb0678748c2" xlink:href="cpix-20221231.xsd#cpix_LesseeOperatingLeaseNumberOfRenewalTerms"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_914dba70-c6c6-438c-838b-7824ac252578" xlink:to="loc_cpix_LesseeOperatingLeaseNumberOfRenewalTerms_c213b133-359f-44aa-ac72-4fb0678748c2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_0274bb70-e6b5-4f65-b51d-0acd4690decc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseRenewalTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_914dba70-c6c6-438c-838b-7824ac252578" xlink:to="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_0274bb70-e6b5-4f65-b51d-0acd4690decc" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_LesseeOperatingLeaseBaseRent_c1eabe82-7a5f-44e0-a78a-f719bcc35b83" xlink:href="cpix-20221231.xsd#cpix_LesseeOperatingLeaseBaseRent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_914dba70-c6c6-438c-838b-7824ac252578" xlink:to="loc_cpix_LesseeOperatingLeaseBaseRent_c1eabe82-7a5f-44e0-a78a-f719bcc35b83" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_LesseeOperatingLeaseRentIncrease_b29eb0ce-eee7-4d51-be66-1ac935e998f0" xlink:href="cpix-20221231.xsd#cpix_LesseeOperatingLeaseRentIncrease"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_914dba70-c6c6-438c-838b-7824ac252578" xlink:to="loc_cpix_LesseeOperatingLeaseRentIncrease_b29eb0ce-eee7-4d51-be66-1ac935e998f0" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AreaOfRealEstateProperty_19dc7e6d-bdc0-4a9c-a154-9c86a1644fbc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AreaOfRealEstateProperty"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_914dba70-c6c6-438c-838b-7824ac252578" xlink:to="loc_us-gaap_AreaOfRealEstateProperty_19dc7e6d-bdc0-4a9c-a154-9c86a1644fbc" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1_6dde928b-21d6-4d1b-abf9-28f26a320a5a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_914dba70-c6c6-438c-838b-7824ac252578" xlink:to="loc_us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1_6dde928b-21d6-4d1b-abf9-28f26a320a5a" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent_9b3676c8-2d3c-48e8-a7d4-d8d4621638f1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_914dba70-c6c6-438c-838b-7824ac252578" xlink:to="loc_us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent_9b3676c8-2d3c-48e8-a7d4-d8d4621638f1" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceived_133e29d5-19a6-46b2-ad2e-62aebf937341" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LessorOperatingLeasePaymentsToBeReceived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_914dba70-c6c6-438c-838b-7824ac252578" xlink:to="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceived_133e29d5-19a6-46b2-ad2e-62aebf937341" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionTable_6de20ab2-0db0-478d-8668-7bd7556aa0e0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeLeaseDescriptionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_914dba70-c6c6-438c-838b-7824ac252578" xlink:to="loc_us-gaap_LesseeLeaseDescriptionTable_6de20ab2-0db0-478d-8668-7bd7556aa0e0" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_b695e479-6232-41df-a40c-e98fca32ee9d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_6de20ab2-0db0-478d-8668-7bd7556aa0e0" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_b695e479-6232-41df-a40c-e98fca32ee9d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_b695e479-6232-41df-a40c-e98fca32ee9d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_b695e479-6232-41df-a40c-e98fca32ee9d" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_b695e479-6232-41df-a40c-e98fca32ee9d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_37f2fc71-83be-430c-87c5-b4f649c3a13f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_b695e479-6232-41df-a40c-e98fca32ee9d" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_37f2fc71-83be-430c-87c5-b4f649c3a13f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OfficeBuildingMember_e1dd47d1-9d85-426b-8fb9-4fbbe7538498" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_OfficeBuildingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_37f2fc71-83be-430c-87c5-b4f649c3a13f" xlink:to="loc_srt_OfficeBuildingMember_e1dd47d1-9d85-426b-8fb9-4fbbe7538498" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseContractualTermAxis_17327fd2-e69b-4fd3-ad60-f7903f8fa74f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseContractualTermAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_6de20ab2-0db0-478d-8668-7bd7556aa0e0" xlink:to="loc_us-gaap_LeaseContractualTermAxis_17327fd2-e69b-4fd3-ad60-f7903f8fa74f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseContractualTermDomain_17327fd2-e69b-4fd3-ad60-f7903f8fa74f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseContractualTermDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LeaseContractualTermAxis_17327fd2-e69b-4fd3-ad60-f7903f8fa74f" xlink:to="loc_us-gaap_LeaseContractualTermDomain_17327fd2-e69b-4fd3-ad60-f7903f8fa74f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseContractualTermDomain_824fd777-bd0c-49e9-b5d0-a1cdded81a18" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseContractualTermDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LeaseContractualTermAxis_17327fd2-e69b-4fd3-ad60-f7903f8fa74f" xlink:to="loc_us-gaap_LeaseContractualTermDomain_824fd777-bd0c-49e9-b5d0-a1cdded81a18" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_BroadwestLeaseFiveYearRenewalOptionMember_a704de9e-3d27-4b0b-91bd-5105521e2d7f" xlink:href="cpix-20221231.xsd#cpix_BroadwestLeaseFiveYearRenewalOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LeaseContractualTermDomain_824fd777-bd0c-49e9-b5d0-a1cdded81a18" xlink:to="loc_cpix_BroadwestLeaseFiveYearRenewalOptionMember_a704de9e-3d27-4b0b-91bd-5105521e2d7f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_fe6ad33c-05b3-41df-9ec6-e0d7e7864202" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_6de20ab2-0db0-478d-8668-7bd7556aa0e0" xlink:to="loc_srt_CounterpartyNameAxis_fe6ad33c-05b3-41df-9ec6-e0d7e7864202" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_fe6ad33c-05b3-41df-9ec6-e0d7e7864202_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_fe6ad33c-05b3-41df-9ec6-e0d7e7864202" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_fe6ad33c-05b3-41df-9ec6-e0d7e7864202_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_71fa0de1-0773-48b2-829f-54a7c9dc6c93" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_fe6ad33c-05b3-41df-9ec6-e0d7e7864202" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_71fa0de1-0773-48b2-829f-54a7c9dc6c93" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_A1600WestEndAvenuePartnersLLCMember_1d87227a-3096-4c6d-bfeb-16d7a698e819" xlink:href="cpix-20221231.xsd#cpix_A1600WestEndAvenuePartnersLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_71fa0de1-0773-48b2-829f-54a7c9dc6c93" xlink:to="loc_cpix_A1600WestEndAvenuePartnersLLCMember_1d87227a-3096-4c6d-bfeb-16d7a698e819" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_CETMember_9ce1335a-a238-441a-9537-b9eca3c20025" xlink:href="cpix-20221231.xsd#cpix_CETMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_71fa0de1-0773-48b2-829f-54a7c9dc6c93" xlink:to="loc_cpix_CETMember_9ce1335a-a238-441a-9537-b9eca3c20025" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cumberlandpharma.com/role/MarketConcentrationsScheduleofRevenuesConcentrationfromMajorCustomersandNarrativeDetails" xlink:type="simple" xlink:href="cpix-20221231.xsd#MarketConcentrationsScheduleofRevenuesConcentrationfromMajorCustomersandNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.cumberlandpharma.com/role/MarketConcentrationsScheduleofRevenuesConcentrationfromMajorCustomersandNarrativeDetails" xlink:type="extended" id="i4a3f51c69446411d8b4091f67da28b83_MarketConcentrationsScheduleofRevenuesConcentrationfromMajorCustomersandNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskLineItems_10b8812b-c5c3-4b3d-91bb-a9bff9f6284e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_6628b222-3b5b-43e3-90bc-16d7ff214b2d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskPercentage1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_10b8812b-c5c3-4b3d-91bb-a9bff9f6284e" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_6628b222-3b5b-43e3-90bc-16d7ff214b2d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTable_560ecddf-2e63-42c9-ae38-87df639e9abd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_10b8812b-c5c3-4b3d-91bb-a9bff9f6284e" xlink:to="loc_us-gaap_ConcentrationRiskTable_560ecddf-2e63-42c9-ae38-87df639e9abd" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_0b4ddd24-4be2-4e77-8342-bfa453fa0a21" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_560ecddf-2e63-42c9-ae38-87df639e9abd" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_0b4ddd24-4be2-4e77-8342-bfa453fa0a21" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_0b4ddd24-4be2-4e77-8342-bfa453fa0a21_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_0b4ddd24-4be2-4e77-8342-bfa453fa0a21" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_0b4ddd24-4be2-4e77-8342-bfa453fa0a21_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_30508235-0144-422a-b80b-6a9ba000d747" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_0b4ddd24-4be2-4e77-8342-bfa453fa0a21" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_30508235-0144-422a-b80b-6a9ba000d747" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerConcentrationRiskMember_dcb442bf-8ef6-4373-908e-483caff49b67" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CustomerConcentrationRiskMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_30508235-0144-422a-b80b-6a9ba000d747" xlink:to="loc_us-gaap_CustomerConcentrationRiskMember_dcb442bf-8ef6-4373-908e-483caff49b67" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_33f0ed98-58aa-4c84-98f6-71d25a41be56" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_560ecddf-2e63-42c9-ae38-87df639e9abd" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_33f0ed98-58aa-4c84-98f6-71d25a41be56" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_33f0ed98-58aa-4c84-98f6-71d25a41be56_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_33f0ed98-58aa-4c84-98f6-71d25a41be56" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_33f0ed98-58aa-4c84-98f6-71d25a41be56_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_92a9187a-16e4-46fa-b4a4-ce8d84cf60b8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_33f0ed98-58aa-4c84-98f6-71d25a41be56" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_92a9187a-16e4-46fa-b4a4-ce8d84cf60b8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_SalesRevenueGoodsGrossMember_149039c3-bb8e-4d07-bc93-c7ee3fc23532" xlink:href="cpix-20221231.xsd#cpix_SalesRevenueGoodsGrossMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_92a9187a-16e4-46fa-b4a4-ce8d84cf60b8" xlink:to="loc_cpix_SalesRevenueGoodsGrossMember_149039c3-bb8e-4d07-bc93-c7ee3fc23532" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableMember_7fa54987-6ec3-4165-9e52-b75dec0467df" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsReceivableMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_92a9187a-16e4-46fa-b4a4-ce8d84cf60b8" xlink:to="loc_us-gaap_AccountsReceivableMember_7fa54987-6ec3-4165-9e52-b75dec0467df" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MajorCustomersAxis_fe26cb1c-de4b-4442-8e3c-3251c2c080a4" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MajorCustomersAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_560ecddf-2e63-42c9-ae38-87df639e9abd" xlink:to="loc_srt_MajorCustomersAxis_fe26cb1c-de4b-4442-8e3c-3251c2c080a4" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_fe26cb1c-de4b-4442-8e3c-3251c2c080a4_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_MajorCustomersAxis_fe26cb1c-de4b-4442-8e3c-3251c2c080a4" xlink:to="loc_srt_NameOfMajorCustomerDomain_fe26cb1c-de4b-4442-8e3c-3251c2c080a4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_361c18e4-a8ba-4433-aaab-d5c824451843" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_MajorCustomersAxis_fe26cb1c-de4b-4442-8e3c-3251c2c080a4" xlink:to="loc_srt_NameOfMajorCustomerDomain_361c18e4-a8ba-4433-aaab-d5c824451843" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_CustomerOneMember_8f2e5466-c3d4-4575-a6bc-d36dc26db880" xlink:href="cpix-20221231.xsd#cpix_CustomerOneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_361c18e4-a8ba-4433-aaab-d5c824451843" xlink:to="loc_cpix_CustomerOneMember_8f2e5466-c3d4-4575-a6bc-d36dc26db880" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_CustomerTwoMember_9ed53059-0885-409a-a2ad-5b649417186f" xlink:href="cpix-20221231.xsd#cpix_CustomerTwoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_361c18e4-a8ba-4433-aaab-d5c824451843" xlink:to="loc_cpix_CustomerTwoMember_9ed53059-0885-409a-a2ad-5b649417186f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_CustomerThreeMember_42390a9c-d1e0-422d-8ce7-7ce1cd8f9d49" xlink:href="cpix-20221231.xsd#cpix_CustomerThreeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_361c18e4-a8ba-4433-aaab-d5c824451843" xlink:to="loc_cpix_CustomerThreeMember_42390a9c-d1e0-422d-8ce7-7ce1cd8f9d49" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_Customer12And3Member_cd8bfc70-6521-48c2-8975-7bed7b7c4807" xlink:href="cpix-20221231.xsd#cpix_Customer12And3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_361c18e4-a8ba-4433-aaab-d5c824451843" xlink:to="loc_cpix_Customer12And3Member_cd8bfc70-6521-48c2-8975-7bed7b7c4807" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cumberlandpharma.com/role/ManufacturingandSupplyAgreementsManufacturingandSupplyAgreementsNarrativeDetails" xlink:type="simple" xlink:href="cpix-20221231.xsd#ManufacturingandSupplyAgreementsManufacturingandSupplyAgreementsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.cumberlandpharma.com/role/ManufacturingandSupplyAgreementsManufacturingandSupplyAgreementsNarrativeDetails" xlink:type="extended" id="ie1d8de08a2614f15af6f757c8211ba09_ManufacturingandSupplyAgreementsManufacturingandSupplyAgreementsNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_cpix_ManufacturingandSupplyAgreementLineItems_e02aae50-3c9d-4d53-b1d9-4735567e0cf6" xlink:href="cpix-20221231.xsd#cpix_ManufacturingandSupplyAgreementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_ManufacturingAgreementsNumberOfPrimarySuppliersForEachProduct_03f026ee-758d-46b9-a57e-7b2307fd6f4a" xlink:href="cpix-20221231.xsd#cpix_ManufacturingAgreementsNumberOfPrimarySuppliersForEachProduct"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cpix_ManufacturingandSupplyAgreementLineItems_e02aae50-3c9d-4d53-b1d9-4735567e0cf6" xlink:to="loc_cpix_ManufacturingAgreementsNumberOfPrimarySuppliersForEachProduct_03f026ee-758d-46b9-a57e-7b2307fd6f4a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_ManufacturingandSupplyAgreementTable_136704e0-6b9b-4035-a852-3199cc434887" xlink:href="cpix-20221231.xsd#cpix_ManufacturingandSupplyAgreementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_cpix_ManufacturingandSupplyAgreementLineItems_e02aae50-3c9d-4d53-b1d9-4735567e0cf6" xlink:to="loc_cpix_ManufacturingandSupplyAgreementTable_136704e0-6b9b-4035-a852-3199cc434887" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_d3277d32-ae18-4251-9dfd-1ef74f7de6c6" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_cpix_ManufacturingandSupplyAgreementTable_136704e0-6b9b-4035-a852-3199cc434887" xlink:to="loc_srt_RangeAxis_d3277d32-ae18-4251-9dfd-1ef74f7de6c6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_d3277d32-ae18-4251-9dfd-1ef74f7de6c6_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_d3277d32-ae18-4251-9dfd-1ef74f7de6c6" xlink:to="loc_srt_RangeMember_d3277d32-ae18-4251-9dfd-1ef74f7de6c6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_7b8dd36d-e150-4e79-83fc-87af6b0e4fbe" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_d3277d32-ae18-4251-9dfd-1ef74f7de6c6" xlink:to="loc_srt_RangeMember_7b8dd36d-e150-4e79-83fc-87af6b0e4fbe" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_6992c413-e90a-4ad2-aba7-b7bc784043a5" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_7b8dd36d-e150-4e79-83fc-87af6b0e4fbe" xlink:to="loc_srt_MinimumMember_6992c413-e90a-4ad2-aba7-b7bc784043a5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_eb2a2d52-6abb-4805-a692-6233e8828889" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_7b8dd36d-e150-4e79-83fc-87af6b0e4fbe" xlink:to="loc_srt_MaximumMember_eb2a2d52-6abb-4805-a692-6233e8828889" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cumberlandpharma.com/role/CommitmentsandContingenciesDetails" xlink:type="simple" xlink:href="cpix-20221231.xsd#CommitmentsandContingenciesDetails"/>
  <link:definitionLink xlink:role="http://www.cumberlandpharma.com/role/CommitmentsandContingenciesDetails" xlink:type="extended" id="ica29b3abb24e410581eb3cf84e858379_CommitmentsandContingenciesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCommitmentsLineItems_cdbb8884-b1e0-438d-b485-8b93a5d8b985" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherCommitmentsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_CollaborativeArrangementRightsAndObligationsSalesMilestonePaymentsMaximum_648a0e9f-cf1f-493d-9503-c4a53adf5659" xlink:href="cpix-20221231.xsd#cpix_CollaborativeArrangementRightsAndObligationsSalesMilestonePaymentsMaximum"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherCommitmentsLineItems_cdbb8884-b1e0-438d-b485-8b93a5d8b985" xlink:to="loc_cpix_CollaborativeArrangementRightsAndObligationsSalesMilestonePaymentsMaximum_648a0e9f-cf1f-493d-9503-c4a53adf5659" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_CollaborativeArrangementRightsAndObligationsTieredRoyaltyPercent_028269ef-7990-4a80-b941-619d1e9964d6" xlink:href="cpix-20221231.xsd#cpix_CollaborativeArrangementRightsAndObligationsTieredRoyaltyPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherCommitmentsLineItems_cdbb8884-b1e0-438d-b485-8b93a5d8b985" xlink:to="loc_cpix_CollaborativeArrangementRightsAndObligationsTieredRoyaltyPercent_028269ef-7990-4a80-b941-619d1e9964d6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_CollaborativeArrangementRightsAndObligationsTerm_3319ef1d-accb-4082-b10b-52b9607eec65" xlink:href="cpix-20221231.xsd#cpix_CollaborativeArrangementRightsAndObligationsTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherCommitmentsLineItems_cdbb8884-b1e0-438d-b485-8b93a5d8b985" xlink:to="loc_cpix_CollaborativeArrangementRightsAndObligationsTerm_3319ef1d-accb-4082-b10b-52b9607eec65" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_CollaborativeArrangementRightsAndObligationsSalesMilestonePaymentsReceivable_938066b3-9ae7-4678-b14a-7049b984ca26" xlink:href="cpix-20221231.xsd#cpix_CollaborativeArrangementRightsAndObligationsSalesMilestonePaymentsReceivable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherCommitmentsLineItems_cdbb8884-b1e0-438d-b485-8b93a5d8b985" xlink:to="loc_cpix_CollaborativeArrangementRightsAndObligationsSalesMilestonePaymentsReceivable_938066b3-9ae7-4678-b14a-7049b984ca26" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainContingencyUnrecordedAmount_325db824-c44d-4ed9-9f3b-852b35a4bbca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainContingencyUnrecordedAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherCommitmentsLineItems_cdbb8884-b1e0-438d-b485-8b93a5d8b985" xlink:to="loc_us-gaap_GainContingencyUnrecordedAmount_325db824-c44d-4ed9-9f3b-852b35a4bbca" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCommitmentsTable_2ed970da-0c68-49ef-a7d3-93d4199a8411" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherCommitmentsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_OtherCommitmentsLineItems_cdbb8884-b1e0-438d-b485-8b93a5d8b985" xlink:to="loc_us-gaap_OtherCommitmentsTable_2ed970da-0c68-49ef-a7d3-93d4199a8411" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_bc61ab94-5b83-4de8-b0b3-d06fc589cd7c" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OtherCommitmentsTable_2ed970da-0c68-49ef-a7d3-93d4199a8411" xlink:to="loc_srt_CounterpartyNameAxis_bc61ab94-5b83-4de8-b0b3-d06fc589cd7c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_bc61ab94-5b83-4de8-b0b3-d06fc589cd7c_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_bc61ab94-5b83-4de8-b0b3-d06fc589cd7c" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_bc61ab94-5b83-4de8-b0b3-d06fc589cd7c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_b5236743-ac42-4552-80cd-f4c399083804" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_bc61ab94-5b83-4de8-b0b3-d06fc589cd7c" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_b5236743-ac42-4552-80cd-f4c399083804" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_KyowaKirinMember_bb8d2ac2-c6ff-4d95-80ae-7e6f78bc27cf" xlink:href="cpix-20221231.xsd#cpix_KyowaKirinMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_b5236743-ac42-4552-80cd-f4c399083804" xlink:to="loc_cpix_KyowaKirinMember_bb8d2ac2-c6ff-4d95-80ae-7e6f78bc27cf" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_MelintaTherapeuticsLLCAndTargantaTherapeuticsCorporationMember_6c515772-310a-465a-a34d-c29a43bbeb26" xlink:href="cpix-20221231.xsd#cpix_MelintaTherapeuticsLLCAndTargantaTherapeuticsCorporationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_b5236743-ac42-4552-80cd-f4c399083804" xlink:to="loc_cpix_MelintaTherapeuticsLLCAndTargantaTherapeuticsCorporationMember_6c515772-310a-465a-a34d-c29a43bbeb26" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_3d702c31-b31e-40db-a479-4fa3bc5bb6e4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OtherCommitmentsTable_2ed970da-0c68-49ef-a7d3-93d4199a8411" xlink:to="loc_us-gaap_TypeOfArrangementAxis_3d702c31-b31e-40db-a479-4fa3bc5bb6e4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_3d702c31-b31e-40db-a479-4fa3bc5bb6e4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_3d702c31-b31e-40db-a479-4fa3bc5bb6e4" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_3d702c31-b31e-40db-a479-4fa3bc5bb6e4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_0d8e930f-d43a-4595-8a51-2fe8da4658af" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_3d702c31-b31e-40db-a479-4fa3bc5bb6e4" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_0d8e930f-d43a-4595-8a51-2fe8da4658af" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementTransactionWithPartyToCollaborativeArrangementMember_7803ceee-63b8-4283-beab-38fe5e125ad7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CollaborativeArrangementTransactionWithPartyToCollaborativeArrangementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_0d8e930f-d43a-4595-8a51-2fe8da4658af" xlink:to="loc_us-gaap_CollaborativeArrangementTransactionWithPartyToCollaborativeArrangementMember_7803ceee-63b8-4283-beab-38fe5e125ad7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_318659f8-b684-465f-ac7e-02078a2a1a79" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OtherCommitmentsTable_2ed970da-0c68-49ef-a7d3-93d4199a8411" xlink:to="loc_srt_RangeAxis_318659f8-b684-465f-ac7e-02078a2a1a79" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_318659f8-b684-465f-ac7e-02078a2a1a79_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_318659f8-b684-465f-ac7e-02078a2a1a79" xlink:to="loc_srt_RangeMember_318659f8-b684-465f-ac7e-02078a2a1a79_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_c2623a01-4f0b-439d-8a38-0c9820ba239d" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_318659f8-b684-465f-ac7e-02078a2a1a79" xlink:to="loc_srt_RangeMember_c2623a01-4f0b-439d-8a38-0c9820ba239d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_9fcf7f59-cd4c-411e-889d-fa19b6e8fbbb" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_c2623a01-4f0b-439d-8a38-0c9820ba239d" xlink:to="loc_srt_MinimumMember_9fcf7f59-cd4c-411e-889d-fa19b6e8fbbb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_f1a888b4-7952-4d00-b473-cfc1ef80e295" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_c2623a01-4f0b-439d-8a38-0c9820ba239d" xlink:to="loc_srt_MaximumMember_f1a888b4-7952-4d00-b473-cfc1ef80e295" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_CollaborativeArrangementMilestonePaymentThresholdAxis_cd9c4f45-5481-4e4f-905e-35d190a2e687" xlink:href="cpix-20221231.xsd#cpix_CollaborativeArrangementMilestonePaymentThresholdAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OtherCommitmentsTable_2ed970da-0c68-49ef-a7d3-93d4199a8411" xlink:to="loc_cpix_CollaborativeArrangementMilestonePaymentThresholdAxis_cd9c4f45-5481-4e4f-905e-35d190a2e687" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_CollaborativeArrangementMilestonePaymentThresholdDomain_cd9c4f45-5481-4e4f-905e-35d190a2e687_default" xlink:href="cpix-20221231.xsd#cpix_CollaborativeArrangementMilestonePaymentThresholdDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_cpix_CollaborativeArrangementMilestonePaymentThresholdAxis_cd9c4f45-5481-4e4f-905e-35d190a2e687" xlink:to="loc_cpix_CollaborativeArrangementMilestonePaymentThresholdDomain_cd9c4f45-5481-4e4f-905e-35d190a2e687_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_CollaborativeArrangementMilestonePaymentThresholdDomain_874cea0a-4fef-452b-9727-74b098acdadb" xlink:href="cpix-20221231.xsd#cpix_CollaborativeArrangementMilestonePaymentThresholdDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_cpix_CollaborativeArrangementMilestonePaymentThresholdAxis_cd9c4f45-5481-4e4f-905e-35d190a2e687" xlink:to="loc_cpix_CollaborativeArrangementMilestonePaymentThresholdDomain_874cea0a-4fef-452b-9727-74b098acdadb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_Within30DaysOfFirstSNDAFilingMember_e67395ae-47d4-4302-b755-a66030cab6cf" xlink:href="cpix-20221231.xsd#cpix_Within30DaysOfFirstSNDAFilingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cpix_CollaborativeArrangementMilestonePaymentThresholdDomain_874cea0a-4fef-452b-9727-74b098acdadb" xlink:to="loc_cpix_Within30DaysOfFirstSNDAFilingMember_e67395ae-47d4-4302-b755-a66030cab6cf" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cpix_FollowingApprovalOfFirstSNDAMember_462b1f6e-a61e-4150-af18-451b449730cc" xlink:href="cpix-20221231.xsd#cpix_FollowingApprovalOfFirstSNDAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cpix_CollaborativeArrangementMilestonePaymentThresholdDomain_874cea0a-4fef-452b-9727-74b098acdadb" xlink:to="loc_cpix_FollowingApprovalOfFirstSNDAMember_462b1f6e-a61e-4150-af18-451b449730cc" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.cumberlandpharma.com/role/ValuationandQualifyingAccountsDetails" xlink:type="simple" xlink:href="cpix-20221231.xsd#ValuationandQualifyingAccountsDetails"/>
  <link:definitionLink xlink:role="http://www.cumberlandpharma.com/role/ValuationandQualifyingAccountsDetails" xlink:type="extended" id="iea4b57ac84544836bf93cd9758d8570c_ValuationandQualifyingAccountsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_79cc44f4-584c-4837-aa32-f4077b167c69" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ValuationAndQualifyingAccountsDisclosureLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_59726f02-a364-410d-92f2-dbe4a6880a3b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MovementInValuationAllowancesAndReservesRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_79cc44f4-584c-4837-aa32-f4077b167c69" xlink:to="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_59726f02-a364-410d-92f2-dbe4a6880a3b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesBalance_e06032e3-3746-41e7-b135-ee8109b4a272" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesBalance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_59726f02-a364-410d-92f2-dbe4a6880a3b" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesBalance_e06032e3-3746-41e7-b135-ee8109b4a272" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense_b31fe19d-22e4-4192-9a73-903f8caad503" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_59726f02-a364-410d-92f2-dbe4a6880a3b" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense_b31fe19d-22e4-4192-9a73-903f8caad503" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesChargedToOtherAccounts_41704278-72bb-4ea4-9ff3-3f1ca745daea" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesChargedToOtherAccounts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_59726f02-a364-410d-92f2-dbe4a6880a3b" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesChargedToOtherAccounts_41704278-72bb-4ea4-9ff3-3f1ca745daea" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDeductions_90441133-9be9-487b-8bcd-a9a3b4a09d15" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesDeductions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_59726f02-a364-410d-92f2-dbe4a6880a3b" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDeductions_90441133-9be9-487b-8bcd-a9a3b4a09d15" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesBalance_c3d900bf-0b12-4d31-b763-af70d01e0e5b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesBalance"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_ef3d3457-9499-4bd5-86e1-bc1b9c3a401e" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ValuationAndQualifyingAccountsDisclosureTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_79cc44f4-584c-4837-aa32-f4077b167c69" xlink:to="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_ef3d3457-9499-4bd5-86e1-bc1b9c3a401e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_eb62f759-8cdb-4b37-8f6f-e0700df14bec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_ef3d3457-9499-4bd5-86e1-bc1b9c3a401e" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_eb62f759-8cdb-4b37-8f6f-e0700df14bec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDomain_eb62f759-8cdb-4b37-8f6f-e0700df14bec_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_eb62f759-8cdb-4b37-8f6f-e0700df14bec" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDomain_eb62f759-8cdb-4b37-8f6f-e0700df14bec_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDomain_3dd02d38-8ef4-4978-9cb3-1f40e6cec0a5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_eb62f759-8cdb-4b37-8f6f-e0700df14bec" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDomain_3dd02d38-8ef4-4978-9cb3-1f40e6cec0a5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForCreditLossMember_d3a507db-c6da-45ec-a00d-c1adb16bd4ed" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AllowanceForCreditLossMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesDomain_3dd02d38-8ef4-4978-9cb3-1f40e6cec0a5" xlink:to="loc_us-gaap_AllowanceForCreditLossMember_d3a507db-c6da-45ec-a00d-c1adb16bd4ed" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowanceOfDeferredTaxAssetsMember_59111c75-aaf0-472b-ae35-c795fa27dd57" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowanceOfDeferredTaxAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesDomain_3dd02d38-8ef4-4978-9cb3-1f40e6cec0a5" xlink:to="loc_us-gaap_ValuationAllowanceOfDeferredTaxAssetsMember_59111c75-aaf0-472b-ae35-c795fa27dd57" xlink:type="arc" order="1"/>
  </link:definitionLink>
</link:linkbase>
