<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2025 Workiva-->
<!--r:be4ad071-f8db-4422-a8d5-c3dfd2ef5d42,g:40fb8e3d-d71e-45bf-a880-4a378dba2868-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://cumberlandpharma.com/role/DocumentandEntityInformationDocument" xlink:type="simple" xlink:href="cpix-20250304.xsd#DocumentandEntityInformationDocument"/>
  <link:presentationLink xlink:role="http://cumberlandpharma.com/role/DocumentandEntityInformationDocument" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_74a672f1-bcf2-4c6e-84c7-a311e84b6360" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_661694f0-9679-4982-ad08-5abbcb3ba88e" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_74a672f1-bcf2-4c6e-84c7-a311e84b6360" xlink:to="loc_dei_DocumentType_661694f0-9679-4982-ad08-5abbcb3ba88e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_ba135e8b-22d1-4bea-b567-a7a746817bb4" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_74a672f1-bcf2-4c6e-84c7-a311e84b6360" xlink:to="loc_dei_DocumentPeriodEndDate_ba135e8b-22d1-4bea-b567-a7a746817bb4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_8b277b6f-3ed7-4d54-ad89-6b7bbef865f1" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_74a672f1-bcf2-4c6e-84c7-a311e84b6360" xlink:to="loc_dei_EntityRegistrantName_8b277b6f-3ed7-4d54-ad89-6b7bbef865f1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_06ba4b6e-7141-444a-9166-9ed2253c144d" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_74a672f1-bcf2-4c6e-84c7-a311e84b6360" xlink:to="loc_dei_EntityCentralIndexKey_06ba4b6e-7141-444a-9166-9ed2253c144d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_761a1066-d91c-4810-a3a0-8e2a69ed85fc" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_74a672f1-bcf2-4c6e-84c7-a311e84b6360" xlink:to="loc_dei_AmendmentFlag_761a1066-d91c-4810-a3a0-8e2a69ed85fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_aadfd02f-f9da-45a8-93fd-95581d352b88" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_74a672f1-bcf2-4c6e-84c7-a311e84b6360" xlink:to="loc_dei_EntityIncorporationStateCountryCode_aadfd02f-f9da-45a8-93fd-95581d352b88" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_e6d15337-0f08-4995-b94d-7b611ebcb483" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_74a672f1-bcf2-4c6e-84c7-a311e84b6360" xlink:to="loc_dei_EntityFileNumber_e6d15337-0f08-4995-b94d-7b611ebcb483" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_fb182edd-209f-48d6-a656-a92cb117de16" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_74a672f1-bcf2-4c6e-84c7-a311e84b6360" xlink:to="loc_dei_EntityTaxIdentificationNumber_fb182edd-209f-48d6-a656-a92cb117de16" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_a203c8f7-75b0-4f55-92f2-da75bfffd737" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_74a672f1-bcf2-4c6e-84c7-a311e84b6360" xlink:to="loc_dei_CityAreaCode_a203c8f7-75b0-4f55-92f2-da75bfffd737" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_f0980467-56e7-448c-9683-138d168b5466" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_74a672f1-bcf2-4c6e-84c7-a311e84b6360" xlink:to="loc_dei_LocalPhoneNumber_f0980467-56e7-448c-9683-138d168b5466" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_a26cbd8d-ea11-412a-b0c5-8203d8806599" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_74a672f1-bcf2-4c6e-84c7-a311e84b6360" xlink:to="loc_dei_WrittenCommunications_a26cbd8d-ea11-412a-b0c5-8203d8806599" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_7ded5ad3-ec17-4aae-87fe-6c4e5bb8c835" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_74a672f1-bcf2-4c6e-84c7-a311e84b6360" xlink:to="loc_dei_SolicitingMaterial_7ded5ad3-ec17-4aae-87fe-6c4e5bb8c835" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_54e7b3b9-995d-4f7c-bfe2-ab13e1ba5184" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_74a672f1-bcf2-4c6e-84c7-a311e84b6360" xlink:to="loc_dei_PreCommencementTenderOffer_54e7b3b9-995d-4f7c-bfe2-ab13e1ba5184" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_e0c5a4f7-243f-4c01-baa2-296107d7b269" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_74a672f1-bcf2-4c6e-84c7-a311e84b6360" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_e0c5a4f7-243f-4c01-baa2-296107d7b269" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_26786fca-7986-4eea-9a01-705ce771d9d6" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_74a672f1-bcf2-4c6e-84c7-a311e84b6360" xlink:to="loc_dei_Security12bTitle_26786fca-7986-4eea-9a01-705ce771d9d6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_48c69bf6-6df6-46e0-8926-8c69f19108ec" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_74a672f1-bcf2-4c6e-84c7-a311e84b6360" xlink:to="loc_dei_TradingSymbol_48c69bf6-6df6-46e0-8926-8c69f19108ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_5dadd37c-4211-4a6f-84bb-5958111cfe75" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_74a672f1-bcf2-4c6e-84c7-a311e84b6360" xlink:to="loc_dei_SecurityExchangeName_5dadd37c-4211-4a6f-84bb-5958111cfe75" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_273314ec-1879-4976-a2e0-6d9166dbee43" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_74a672f1-bcf2-4c6e-84c7-a311e84b6360" xlink:to="loc_dei_EntityEmergingGrowthCompany_273314ec-1879-4976-a2e0-6d9166dbee43" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_8bd1379c-4762-4229-a23a-b73cc73cc45d" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_74a672f1-bcf2-4c6e-84c7-a311e84b6360" xlink:to="loc_dei_EntityAddressAddressLine1_8bd1379c-4762-4229-a23a-b73cc73cc45d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_b66aeadf-f902-4c33-a6f2-b986873ed9d2" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_74a672f1-bcf2-4c6e-84c7-a311e84b6360" xlink:to="loc_dei_EntityAddressPostalZipCode_b66aeadf-f902-4c33-a6f2-b986873ed9d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_57800af5-e879-4cd8-a8b0-7cf8e9216aef" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_74a672f1-bcf2-4c6e-84c7-a311e84b6360" xlink:to="loc_dei_EntityAddressCityOrTown_57800af5-e879-4cd8-a8b0-7cf8e9216aef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_50ed9bed-59f4-437d-a82b-fff98c94135a" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_74a672f1-bcf2-4c6e-84c7-a311e84b6360" xlink:to="loc_dei_EntityAddressStateOrProvince_50ed9bed-59f4-437d-a82b-fff98c94135a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
