<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2023 Workiva-->
<!--r:c86a165f-e85c-4abe-81ea-6fbaf38133c3,g:13940c62-0aa2-4c74-ac53-916de1682fb4-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://cumberlandpharma.com/role/DocumentandEntityInformationDocument" xlink:type="simple" xlink:href="cpix-20231013.xsd#DocumentandEntityInformationDocument"/>
  <link:presentationLink xlink:role="http://cumberlandpharma.com/role/DocumentandEntityInformationDocument" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_f016288e-ea21-4e1f-8f2d-0b2e82a06893" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_5f4f0477-bed0-4379-b0a6-4003a697c4e5" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f016288e-ea21-4e1f-8f2d-0b2e82a06893" xlink:to="loc_dei_DocumentType_5f4f0477-bed0-4379-b0a6-4003a697c4e5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_4085acaf-e69c-4cd3-9c98-288899f9954e" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f016288e-ea21-4e1f-8f2d-0b2e82a06893" xlink:to="loc_dei_DocumentPeriodEndDate_4085acaf-e69c-4cd3-9c98-288899f9954e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_cdcfac72-d74f-4cc5-9ae9-9b7a6dea27a1" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f016288e-ea21-4e1f-8f2d-0b2e82a06893" xlink:to="loc_dei_EntityRegistrantName_cdcfac72-d74f-4cc5-9ae9-9b7a6dea27a1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_7005a839-1ce8-4bfc-9fa3-5b27b57dad08" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f016288e-ea21-4e1f-8f2d-0b2e82a06893" xlink:to="loc_dei_EntityCentralIndexKey_7005a839-1ce8-4bfc-9fa3-5b27b57dad08" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_262dc7cd-03f9-4107-86e6-b7c5baa6f7ae" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f016288e-ea21-4e1f-8f2d-0b2e82a06893" xlink:to="loc_dei_AmendmentFlag_262dc7cd-03f9-4107-86e6-b7c5baa6f7ae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_3b9051cc-0dcf-44c0-baca-29858b601da6" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f016288e-ea21-4e1f-8f2d-0b2e82a06893" xlink:to="loc_dei_EntityIncorporationStateCountryCode_3b9051cc-0dcf-44c0-baca-29858b601da6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_88b6988d-31b8-4078-b9c6-3e9e14624519" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f016288e-ea21-4e1f-8f2d-0b2e82a06893" xlink:to="loc_dei_EntityFileNumber_88b6988d-31b8-4078-b9c6-3e9e14624519" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_3b879f87-a1fa-4c88-8269-57c471b34f0a" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f016288e-ea21-4e1f-8f2d-0b2e82a06893" xlink:to="loc_dei_EntityTaxIdentificationNumber_3b879f87-a1fa-4c88-8269-57c471b34f0a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_65c68ca1-fb8d-4ee8-8a9c-8591dfbf9e30" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f016288e-ea21-4e1f-8f2d-0b2e82a06893" xlink:to="loc_dei_CityAreaCode_65c68ca1-fb8d-4ee8-8a9c-8591dfbf9e30" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_a1615890-e684-4b3d-9373-d463ec3b1cea" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f016288e-ea21-4e1f-8f2d-0b2e82a06893" xlink:to="loc_dei_LocalPhoneNumber_a1615890-e684-4b3d-9373-d463ec3b1cea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_b4437c09-6fee-452b-a4fd-abdcfafb7b20" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f016288e-ea21-4e1f-8f2d-0b2e82a06893" xlink:to="loc_dei_WrittenCommunications_b4437c09-6fee-452b-a4fd-abdcfafb7b20" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_6d595b2c-744d-437f-b1ee-01da7dd1f0b1" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f016288e-ea21-4e1f-8f2d-0b2e82a06893" xlink:to="loc_dei_SolicitingMaterial_6d595b2c-744d-437f-b1ee-01da7dd1f0b1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_c8155409-852e-45a1-a177-58a5b8d60ba8" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f016288e-ea21-4e1f-8f2d-0b2e82a06893" xlink:to="loc_dei_PreCommencementTenderOffer_c8155409-852e-45a1-a177-58a5b8d60ba8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_c19609fd-092f-46d6-90bb-b4b3564f1df8" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f016288e-ea21-4e1f-8f2d-0b2e82a06893" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_c19609fd-092f-46d6-90bb-b4b3564f1df8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_42d432b2-f9a8-4bd1-ae58-87575850fb6a" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f016288e-ea21-4e1f-8f2d-0b2e82a06893" xlink:to="loc_dei_Security12bTitle_42d432b2-f9a8-4bd1-ae58-87575850fb6a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_b5060f8a-1456-4206-aa20-da46cb60b44f" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f016288e-ea21-4e1f-8f2d-0b2e82a06893" xlink:to="loc_dei_TradingSymbol_b5060f8a-1456-4206-aa20-da46cb60b44f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_7c6c15b0-3451-4225-8480-df1c7618d009" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f016288e-ea21-4e1f-8f2d-0b2e82a06893" xlink:to="loc_dei_SecurityExchangeName_7c6c15b0-3451-4225-8480-df1c7618d009" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_c8f71bca-56d9-4e12-94e7-088d64369fc2" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f016288e-ea21-4e1f-8f2d-0b2e82a06893" xlink:to="loc_dei_EntityEmergingGrowthCompany_c8f71bca-56d9-4e12-94e7-088d64369fc2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_86bb93ca-479e-4e65-9478-55cd321fa7da" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f016288e-ea21-4e1f-8f2d-0b2e82a06893" xlink:to="loc_dei_EntityAddressAddressLine1_86bb93ca-479e-4e65-9478-55cd321fa7da" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_d35a224e-3698-4a59-8279-72ae535f6cbb" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f016288e-ea21-4e1f-8f2d-0b2e82a06893" xlink:to="loc_dei_EntityAddressPostalZipCode_d35a224e-3698-4a59-8279-72ae535f6cbb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_a2e9caad-3294-4d8b-ab68-00a7311c45fb" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f016288e-ea21-4e1f-8f2d-0b2e82a06893" xlink:to="loc_dei_EntityAddressCityOrTown_a2e9caad-3294-4d8b-ab68-00a7311c45fb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_9aa6ea71-eaff-4f65-96ef-13f8bfc90b95" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_f016288e-ea21-4e1f-8f2d-0b2e82a06893" xlink:to="loc_dei_EntityAddressStateOrProvince_9aa6ea71-eaff-4f65-96ef-13f8bfc90b95" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
